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X-WR-CALDESC:Events for Beckman Laser Institute
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DTSTART;TZID=UTC:20190425T120000
DTEND;TZID=UTC:20190425T130000
DTSTAMP:20190404T234907Z
CREATED:20190125T041910Z
LAST-MODIFIED:20190404T234907Z
UID:7355-1556193600-1556197200@bli.uci.edu
SUMMARY:Xiaolin Nan\, PhD
DESCRIPTION:Department of Biomedical Engineering\nOregon Health & Sciences University\nPortland\, Oregon \nVisualizing Tumor Biology: From Single Molecules to Systems\nCancer is a systems disease that arises from complex molecular abnormalities\, whereby effective treatment requires insight into tumorigenesis at multiple levels – from individual molecules to whole cells and tumors. Research in our laboratory aims to build multiscale\, systems-level models of tumorigenic signaling by leveraging recent developments in single-molecule\, superresolution\, and correlative light – electron microscopies. Using the human epidermal growth factor receptors (e.g. HER2) and the Ras small GTPases as model systems\, we will showcase how quantitative imaging at the single-molecule and nanometer scales reveals previously unknown aspects of these common oncogenic drivers. These findings underscore the importance of studying tumor biology within the intact spatial and biological context\, which current omics-based systems-biology approaches have largely overlooked. We will also discuss ongoing efforts toward constructing spatially-integrated models of tumorigenic signaling networks through multiplexed and high-throughput superresolution imaging\, as well as the implications of our findings in targeted cancer therapies. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Eric Potma
URL:https://bli.uci.edu/event/xiaolin-nan-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/01/nan.jpg
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