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DTSTART;TZID=America/Los_Angeles:20220818T120000
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DTSTAMP:20220811T163904Z
CREATED:20220811T162605Z
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UID:30894-1660824000-1660827600@bli.uci.edu
SUMMARY:Jason B. King\, Ph. D.
DESCRIPTION:  \nLaser Beam Shaping for Surgery and Microbiopsy \nAbstract \nLasers are increasingly being used for surgery in a wide range of medical specialties due to their advantages over alternative\nsurgical tools. Advantages include precise material removal\, limited bleeding\, and delivery through optical fibers enabling use\nin body cavities and for minimally invasive surgeries. Advancements in laser technology including new laser wavelengths and\nhigher power continue to improve the performance and implementation of surgical lasers. Temporal beam shaping\, or pulse\nmodulation\, has been implemented into clinical laser systems to increase efficiency of urological surgeries\, leading to faster\,\nsafer procedures. However\, the precise mechanisms of temporally shaped laser ablation are not fully understood. The effects\nof spatial beam shaping on laser tissue ablation have not previously been explored.\nWe aim to understand the impact of temporal and spatial laser beam on laser ablation to improve the performance and\nincrease the applications of laser surgery. Working towards this aim\, a Ho:YAG laser was temporally and spatially altered and\nthe effects on tissue ablation were explored. We explored the mechanisms of pulse modulated ablation through experiments\non phantoms and native kidney stones. We discovered that increased ablation efficiency by pulse modulation is composition\ndependent. Next\, increased ablation efficiency by altering laser spatial shape was explored. We discovered that shaping the\nlaser beam into an annular shape led to an increase in ablation efficiency in both hard and soft tissues. Finally\, we explored\nthe application of spatially shaped laser ablation for laser microbiopsy to harvest sub-microliter (<1 mm3) tissue samples.\nLaser beam shaping\, pulse energy\, and application of cryogen spray cooling were optimized to successfully harvest tissue\nsections with observable histological features. Harvested tissues were imaged with confocal microscopy and “virtual H&E”\nmethods were used to digitally color the images to mimic H&E stained tissue sections. Laser microbiopsy with virtual H&E is\nminimally invasive\, precise\, and provides images in a fraction of the time of the traditional pathology workflow. \n  \nBiography \nDr. Jason King recently graduated with his PhD in biomedical engineering from the University of Texas at Austin. His work\nfocuses on optimization of laser ablation for surgery and biopsy through temporal and spatial laser beam shaping. This work\nincludes computational modeling and ablation experiments aimed at understanding light tissue interactions involved in laser\nablation. His other research interests include confocal microscopy and Raman spectroscopy for cancer diagnosis and\nmonitoring. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n 
URL:https://bli.uci.edu/event/jason-b-king-ph-d-2/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/08/Jasonbking.jpg
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