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DTSTART;TZID=America/Los_Angeles:20231121T120000
DTEND;TZID=America/Los_Angeles:20231121T130000
DTSTAMP:20260823T103354
CREATED:20250325T212039Z
LAST-MODIFIED:20250325T212039Z
UID:32952-1700568000-1700571600@bli.uci.edu
SUMMARY:Xunbin Wei\, Ph.D.
DESCRIPTION:Light Treatment of Alzheimer’s Disease\nAbstract  \nPhotobiomodulation\, by utilizing low-power light in the visible or near-infrared spectrum to trigger biological responses in cells and tissues\, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD)\, while its specific mechanisms have remained elusive. Here\, we provide evidence that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden\, the hallmark of AD. The glial cells\, including microglia and astrocytes\, play important roles in Aβ clearance. Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice. The 1070-nm light-induced microglia responses with alteration in morphology and increased colocalization with Aβ are sufficient to reduce Aβ load in AD mice. \nMoreover\, we demonstrate that 1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further improve Aβ clearance. Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic\napproach for AD. \nBiography \nDr. Wei received his bachelor in physics from University of Science and Technology of China\, Hefei. He received his PhD from Department of Physiology and Biophysics\, University of California\, Irvine. Dr. Wei completed his post-doc training at Children’s Hospital\, Harvard Medical School. From 2006-2010\, he was a professor in Fudan University\, China. From 2006-2010\, he was a professor and chair in Department of Biomedical Instrumentation\, School of Biomedical Engineering\, Shanghai Jiao Tong University\, China. \nCurrently\, he is a professor at Department of Biomedical Engineering\, Peking University. Dr. Wei is an SPIE Fellow\, and recipient of Chinese Outstanding Young Scholar Award. He has published more than 120 peer-reviewed papers\, including in Nature and PNAS. His research interests include cancer detection by optical means\, optical manipulation of cells\, and light treatment of Alzheimer disease. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n 
URL:https://bli.uci.edu/event/xunbin-wei/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2025/03/Screenshot-2025-03-25-141956.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230808T150000
DTEND;TZID=UTC:20230808T160000
DTSTAMP:20260823T103354
CREATED:20250325T205417Z
LAST-MODIFIED:20250325T205542Z
UID:32940-1691506800-1691510400@bli.uci.edu
SUMMARY:Woonggyu Jung\, Ph.D.
DESCRIPTION:Staining-free optical imaging techniques toward digital histopathology \nAbstract \nThe histological optical imaging is a gold standard method to observe the biological tissues\, which follows routine process such as dissection\, embedding\, sectioning\, staining\, visualization and interpretation of specimens. This technique has a long history of development\, and is used ubiquitously in pathology\, despite being highly time and labour-intensive. Advanced optical imaging techniques developed over the last decade have enabled to provide high sensitivity\, high resolution and non-invasive biological information. In particular\, new optical imaging contrast rather than chemical staining has been presented to be utilized in histopathology while showing the strong potential. However\, acquiring high throughput\, large volume tissue anatomy remains a difficult challenge due to the effect of light scattering\, which limits the penetration imaging depth and lateral resolution. Recently\, various optical imaging methods have been introduced to\ncreate volumetric anatomy data of ex vivo tissues using physical tissue sectioning or optical clearing. \nHere\, we introduce novel staining-free and multi-scale imaging modality based on scattering and phase contrast. Optical staining in histopathology could be key technique to build fast feedback of anatomy of tissues or organs due to its simplicity\, efficiency\, robustness\, and high-throughput capabilities. This presentation covers the latest work of large-scale and fast tissue imaging using optical coherence microscopy\, quantitative phase imaging and projection tomography. Specifically\, the talk will highlight comparison study over the conventional method in histopathology and its adaptation with artificial intelligence such as the virtual staining and resolution enhancement. \nBiography \nWoonggyu Jung received his Ph. D. in 2008 from the Department of Biomedical Engineering at the University of California\, Irvine. From 2001 to 2008\, he worked at the Beckman Laser Institute and Medical Clinic at UC Irvine. He also worked at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign since January 2009. He has joined the faculty of UNIST in 2012\, and currently works as an associate professor of Department of Biomedical Engineering. He is also co-founder and CTO of start-up company\, Conecson which is focused on the futuristic business regarding to mobile-based medical devices. Dr. Jung has a strong research background in optical imaging technologies including optical coherence tomography (OCT)\, quantitative phase microscope (QPM)\, and miniaturized optical imaging probes. His research interest is to develop new optical technologies that address challenges in clinical medicine\, basic biological research and neuroscience. In previous work\, he developed a successful optical platform for in vivo translational research\, and has published more than 60 peer-reviewed journal papers in the field of biophotoics. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Zhongping Chen
URL:https://bli.uci.edu/event/woonggyu-jung-2/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2020/02/Woonggyu-Jung.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230615T120000
DTEND;TZID=America/Los_Angeles:20230615T130000
DTSTAMP:20260823T103354
CREATED:20250325T204318Z
LAST-MODIFIED:20250325T204318Z
UID:32933-1686830400-1686834000@bli.uci.edu
SUMMARY:Hyunmo Yang\, Ph.D.
DESCRIPTION:Deep Learning Applications in Biomedical Imaging\nAbstract  \nRecently developed deep learning techniques revolutionized image analysis methods in the last decade. Classification\, segmentation\, quantitative prediction\, and generating new data can be performed by the training of deep learning models. These tasks can directly be applied to biomedical imaging and successful applications will provide strong advantages to researchers and physicians in terms of efficiency for their studies and improvement in diagnosis. \nIn this talk\, I will discuss my recent studies that using deep learning techniques to the following topics: glaucoma screening from fundus photographs based on regional retinal nerve fiber layer (RNFL) thickness estimation using deep learning\, label-free digital histopathology with QPI imaging based on virtual staining and image classification techniques\, and high-throughput phenotype screening platform using office scanner. For these studies\, we have employed the convolution neural network (CNN) network architectures and trained them to perform image-to-number regression\, image classification\, image segmentation\, and image-to-image generation. The details of each approach will be also discussed. \nBiography \nDr. Hyunmo Yang earned his Ph.D. in physics from Ulsan National Institute of Science of Technology (UNIST) in Korea. After his degree in 2019\, he joined as a postdoc researcher to the translational biophotonics laboratory in department of biomedical engineering at UNIST. He is currently working on developing machine learning and deep learning applications for biomedical imaging. His research interests are digital medicine\, digital screening and digital histopathology using A.I. technology. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n 
URL:https://bli.uci.edu/event/hyunmo-yang/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2025/03/Screenshot-2025-03-25-134139-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230427T120000
DTEND;TZID=America/Los_Angeles:20230427T130000
DTSTAMP:20260823T103354
CREATED:20250325T203342Z
LAST-MODIFIED:20250325T204503Z
UID:32928-1682596800-1682600400@bli.uci.edu
SUMMARY:Roukuya Mamuti\, Ph.D.
DESCRIPTION:Tunable infrared structured laser generation and opto-thermal trapping of micro/nano particles\nAbstract  \nThis talk covers the experimental research and theoretical investigation of mid-infrared tunable optical vortex sources with versatile orbital angular momentum (OAM) and opto-thermophoretic trapping of micro and nano particles with mid-infrared fiber lasers. As a typical structured light\, optical vortex with a helical wavefront exhibits interesting physical properties\, including an annular spatial intensity profile and an OAM of owing to an on-axial phase singularity. Such properties of the vortex beam have been widely utilized in diverse applications. In the talk\, Dr. Mamuti presents generation of optical vortices with versatile OAM states from a nanosecond optical parametric oscillator (OPO) by appropriately shortening or extending the cavity. The system with a compact cavity configuration enables the production of a millijoule-level signal (idler) output with l =1~3 (0~-2) simply by tuning the wavelength of signal output. The system was further developed to create coherently coupled OAM states\, i.e.\, flower-shaped signal and wheel-shaped idler outputs\, arising from the coherent superposition of opposite-signed OAM states. \nFurthermore\, Dr. Mamuti proposed a method for opto-thermophoretic trapping with a 2 μm Tm-doped fiber laser. The infrared continuous-wave laser beam is directly and strongly absorbed by water solution\, and some local temperature gradient is generated around the focus. The particles are migrated along the temperature gradient and form a hexagonal close-packed structure at a bottom-glass solution interface. She has investigated the dependence of the phenomenon on the material\, particle size\, and laser power. Since the water molecules have a significant absorption in the 3-μm wavelength band\, a midinfrared Er:ZBLAN tunable fiber laser is applied for opto-thermophoretic trapping of particles diffusing in water. Through the laser wavelength dependence and single particle tracking analysis\, they found that particles are rapidly collected at the laser focus which is much faster than near infrared lasers. The system with 2 μm and 3 μm direct optothermal trapping could be extended in various fields\, such as bio sensing\, detection\, and sorting. \nBiography \nDr. Roukuya Mamuti received her Master’s and Ph.D. degrees in Optical Engineering from laser laboratory\, Chiba University\, Japan. Her graduate research mainly focused on the generation of tunable infrared structured lasers. After graduation\, she worked as a postdoctoral researcher at Laser Lab (the same lab where she earned her degree). Dr. Mamuti received 2 million Japanese yen of research grant from Kambayashi foundation (private funding). Later\, she worked in the Laser Science Laboratory at Toyota Technological Institute\, to develop optical trapping of micro/nano particles. Now\, she is seeking a research position to pursue her profession in laser-related research fields. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n 
URL:https://bli.uci.edu/event/roukuya-mamuti/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2025/03/Screenshot-2025-03-25-133315.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230420T090000
DTEND;TZID=America/Los_Angeles:20230420T100000
DTSTAMP:20260823T103354
CREATED:20230413T235332Z
LAST-MODIFIED:20250325T201003Z
UID:31266-1681981200-1681984800@bli.uci.edu
SUMMARY:Martin Lavery\, Ph.D.
DESCRIPTION:Environmental and Fiber Sensing with Structured Light \nAbstract  \nStructured light is being widely used to revolutionize the technologies used in optical trapping\, microscopy\, astronomical metrology\, optical communication\, quantum information systems\, and many others. One defines an optical wavefront that has been spatially shaped in its phase\, polarisation or intensity as structured light. Prof. Lavery will present an introduction to the research field and an overview of their work in the Structured Photonics Research Group\, at the University of Glasgow\, in the creation\, detection\, and application of shaped optical beams for a range of sensing applications. He will discuss the development of technologies to generate and measure structured light\, including reconfigurable platforms based on silicon Photonic Integrated Circuits (PICs). \n Further\, he will present their recent advances in utilising structured light for sensing in complex optical environments such as underwater scattering\, atmospheric turbulence\, and multimode optical fibers. They have developed approaches that use spatial mode sensitive receivers to extract features buried in aberrated optical fields that can increase the accuracy of the measurement of particulates in submersed channels\, measure wind speed and temperature from the air\, and sense changes in the shape of optical fibers. These sensors could be used for environmental pollution sensing in water\, failure monitoring in mechanical systems\, and sub-km weather monitoring critical for developing accurate climate models. \nBiography \nProfessor Martin Lavery is a Full Professor in Optics and is the leader of the Structured Photonics Research Group at the James Watt School of Engineering at the University of Glasgow (UofG). Prof. Lavery has a portfolio\nof over $6 million in independent research funding as Principal Investigator (PI) and is leading the H2020 Future and Emerging Technologies (FET-Open) consortium project named SuperPixels\, each of which have an array of international partners from both industry and academia. He has held the prestigious Royal Academy of\nEngineering (RAEng) Research Fellowship from 2014-2019. Prof. Lavery’s H-index is 41 with over 60 publications in peer-reviewed journals and over 80 conference\nmanuscripts that have collectively attracted over 11\,000 citations (Google Scholar\, Dec 2022). He has been awarded the 2013 Scopus Young Scientist of the Year for Physical Sciences\, the 2018 Mobile World Scholar Gold Medal\, and the 2019 Royal Society of Edinburgh Sir Thomas Makdougall Brisbane Medal for accomplishments in\noptical communication and sensing. \nREGISTER HERE FOR ZOOM \n 
URL:https://bli.uci.edu/event/martin-lavery-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2023 Virtual Seminar Series
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2023/04/image.1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230330T090000
DTEND;TZID=America/Los_Angeles:20230330T100000
DTSTAMP:20260823T103354
CREATED:20230328T165357Z
LAST-MODIFIED:20230328T165742Z
UID:31224-1680166800-1680170400@bli.uci.edu
SUMMARY:Daniel Razansky\, Ph.D.
DESCRIPTION:Cardio-oncology; Advanced optoacoustic imaging methods for biomedical research and clinical diagnostics \nAbstract  \nOptoacoustic imaging has achieved remarkable progress over the last decade\, benefiting from coordinated developments in optical and ultrasound technology\, probe chemistry\, and imaging theory. The technique is increasingly attracting attention of the biomedical research community due to its excellent spatial and temporal resolution\, centimeter scale penetration into living tissues\, versatile endogenous and exogenous optical absorption contrast. State-of-the-art implementations of multispectral optoacoustic tomography are based on multi-wavelength excitation of tissues to visualize specific molecules within opaque tissues. As a result\, optoacoustics can noninvasively deliver structural\, functional\, metabolic\, and molecular information from living tissues. \nThe talk covers advances in optoacoustic microscopy and tomography instrumentation\, reconstruction algorithms for ultrafast imaging\, as well as synergistic combinations with fluorescence\, magnetic resonance and ultrasound methods. Efforts are underway to explore potential of the technique in studying multi-scale dynamics of the brain and heart\, monitoring of therapies\, targeted molecular imaging applications and clinical diagnostics of patients in a number of indications\, such as breast and skin lesions\, inflammatory diseases and cardiovascular diagnostics. \nBiography \nProfessor Daniel Razansky holds the Chair of Biomedical Imaging with double appointments at the Faculty of Medicine\, University of Zurich and Department of Information Technologies and Electrical Engineering\, ETH Zurich in Switzerland\, where he also serves as Director of the joint Preclinical Imaging Center. \nHe earned degrees in Biomedical and Electrical Engineering from the Technion – Israel Institute of Technology and conducted postdoctoral research at the Harvard Medical School. Previously\, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich in Germany. \nThe Razansky Lab pioneered a number of bio-imaging technologies that were successfully commercialized and put into use in research labs and clinical facilities across the globe\, among them the multi-spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). His research has been recognized by the German Innovation Prize and multiple awards from the ERC\, NIH\, SNF\, DFG and HFSP. He is also Fellow of the IEEE\, SPIE and Optica Societies. \nREGISTER HERE FOR ZOOM \n 
URL:https://bli.uci.edu/event/daniel-razansky-phd/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2023 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2023/03/updated.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220523T120000
DTEND;TZID=UTC:20220523T130000
DTSTAMP:20260823T103354
CREATED:20220515T163102Z
LAST-MODIFIED:20220515T163335Z
UID:30522-1653307200-1653310800@bli.uci.edu
SUMMARY:Michelle Digman\, Ph. D.
DESCRIPTION:FLIM and Mitometer enable metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells \nAbstract \nThe hallmark of metabolic alteration of increase glycolysis\, i.e. Warburg effect\, in cancer cells together with atypical extracellular matrix structure may be responsible for tumor cell aggressiveness and drug resistance. While it is it known that tumor cells stiffen the ECM as the tumor progression occurs\, a direct relationship between ECM stiffness and altered metabolism has not been explicitly measured. Here we apply the phasor approach technique in fluorescence lifetime imaging microscopy (FLIM) to measure metabolic alteration as a function of ECM mechanics. We imaged and compared triple-negative breast cancer (TNBC) cells to non-cancerous cells on various ECM stiffness. Our results show that TNBC exhibit a decreased fraction of bound NADH\, (indicative of glycolysis\,) with increasing substrate stiffness. All other cell lines showed little to no change in fraction bound NADH on the varying collagen densities. Dysregulation of mitochondrial motion may contribute to the fueling of bioenergy demands in metastatic cancer. To measure mitochondria motion and analyze their fusion and fission events\, we developed a new algorithm called “mitometer” that is unbiased\, and allows for automated segmentation and tracking of mitochondria in live cell 2D and 3D time-lapse images. Together\, the automated segmentation and tracking algorithms and the innate user interface make Mitometer a broadly accessible tool.? \n  \nBiography \nDr. Digman was awarded a doctorate degree in Chemistry with specialization in Biochemistry from the University of Illinois at Chicago in 2003. She did her postdoctoral work in the Department of Physics at the University of Illinois at Urbana-Champaign in biophysics until this lab moved to the University of California Irvine. She became Optical Bio-Core Director until she joined the BME department in 2013. Her research lab is focused on developing novel biophysical and optical tools to study biological questions with the goal of applying the gained knowledge to the advancement of human medicine. Dr. Digman is AIMBE Fellow\, Scialog Fellow\, Allen Distinguished Investigator in Immunometabolism\, and has won several awards including the NSF-CAREER award\, the Hellman Fellowship\, the Fluorescence Young Investigator Award from the Biophysical Society\, the Faculty Innovation in Teaching award and has received the Henry Samueli Career Development Chair \n  \nREGISTER HERE
URL:https://bli.uci.edu/event/michelle-digman-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/05/Digman.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220411T120000
DTEND;TZID=UTC:20220411T130000
DTSTAMP:20260823T103354
CREATED:20220403T121058Z
LAST-MODIFIED:20220403T121821Z
UID:30476-1649678400-1649682000@bli.uci.edu
SUMMARY:Alvin Viray\, J.D.
DESCRIPTION:Technology Transfer and Entrepreneurship at UCI \nAbstract \nThis seminar will discuss “technology transfer”\, the process by which UCI (1) protects intellectual property (inventions and software) developed by its faculty\, staff\, researchers and grad students; and (2) commercializes this IP through licensing to an existing company or startup. Also discussed will be the services and resources at UCI’s Beall Applied Innovation for entrepreneurs willing to form a startup based upon the intellectual property they develop at UCI. If you are currently developing intellectual property (IP) at UCI\, would like to do so\, and/or are curious about entrepreneurship and startups\, this seminar will seek to answer any and all your questions: How to submit your invention/software to UCI’s technology transfer office (aka “Research Translation Group”); Who owns my intellectual property; How much do inventors get from UCI’s licensing deal; What is the services and resources are available to me as an entrepreneur doing a startup? \n  \nBiography \nAlvin Viray is the Associate Director of UC Irvine’s technology transfer office\, known as the Research Translation Group (RTG) at UCI’s Beall Applied Innovation. Alvin and his team receives and manages inventions developed by UCI’s faculty\, physicians\, and researchers. He reviews new invention disclosures for patentability and commercial viability. He negotiates and executes various intellectual property agreements on behalf of UCI\, including license agreements for startups and companies. A licensed patent attorney\, Alvin graduated from the University of San Diego School of Law before passing the California Bar and USPTO Patent Bar. Alvin received his bachelor’s from UCI where he frequently guest lectures on topics covering Patents\, Copyrights\, Trademarks\, Licensing\, and Startups. \n  \nREGISTER HERE
URL:https://bli.uci.edu/event/alvin-viray-j-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/04/Alvin-Viray.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220331T120000
DTEND;TZID=UTC:20220331T130000
DTSTAMP:20260823T103354
CREATED:20220321T225034Z
LAST-MODIFIED:20220403T121006Z
UID:30470-1648728000-1648731600@bli.uci.edu
SUMMARY:David A. Chalyan\, MD\, MSc
DESCRIPTION:Opportunities to Improve Clinical Outcomes with Intravascular Ultrasound (IVUS) in Lower Extremity Revascularizations \nAbstract \nPeripheral vascular disorders are prevalent and mounting health conditions\, particularly in light of the aging population. Both acute and chronic arterial and venous disease result in excess morbidity and mortality and dramatically reduce health-related quality of life. Yet\, despite the expanded indications in guidelines for the types and complexities of vascular lesions resulting in a rising volume of endovascular interventions in general\, we have not seen a meaningful impact on clinical outcomes like amputation rates\, which continue to increase despite better access to peripheral vascular procedures. With the known health outcome benefits of Intravascular Ultrasound (IVUS) in coronary applications and the much higher reintervention rates in peripheral vascular procedures\, the uptake of IVUS has been increasing in lower extremity revascularizations. In this seminar\, we examine the up-to-date evidence\, cross-disciplinary consensus and emerging Real-World Data (RWD) for the role of IVUS in peripheral interventions in order to provide guidance on where this invasive imaging modality may be most beneficial to improve the quality of patient care during lower extremity arterial and venous intervention. \n  \nBiography \nDavid A. Chalyan received his Doctor of Medicine degree from Roy J. and Lucille A. Carver College of Medicine at the University of Iowa and his Master of Science degree in Biomedical Engineering from the University of California\, Irvine where he studied invasive coronary hemodynamics\, angiography-based Fractional Flow Reserve\, and diastolic Fractional Flow Reserve. He currently holds a position in Philips Chief Medical Office \n  \nREGISTER HERE
URL:https://bli.uci.edu/event/david-a-chalyan-md-msc/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/03/Chalyan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220310T120000
DTEND;TZID=UTC:20220310T130000
DTSTAMP:20260823T103354
CREATED:20220301T192752Z
LAST-MODIFIED:20220301T192752Z
UID:30462-1646913600-1646917200@bli.uci.edu
SUMMARY:Dr. Maxim R. Shcherbakov\, Ph. D.
DESCRIPTION:Tunable photonic nanostructures for laser pulse control and dynamic imaging \nAbstract \nFor decades\, nanofabrication has been the driving force behind the transformations in electronics. Light-based devices currently experience a similar transition: nanostructure-based photonic elements bear promise to revolutionize several key technology areas\, such as telecommunications\, augmented reality\, remote sensing\, and imaging. In this talk\, I will introduce the concept of tunable photonic nanostructures\, where time can be leveraged as an additional degree of freedom to manipulate the flow of light on demand. In a multi-faceted study\, we will explore how silicon-based nanostructures can be used as ultrafast all-optical switches that can control light with light at subpicosecond timescales and record-low Joule-per-bit counts. Next\, by marrying designer nanostructures to a technologically mature switching agent\, liquid crystals\, we will demonstrate the world’s thinnest lens with an electrically tunable focal spot. We will conclude on remarks how our technology enables lightweight and compact imaging solutions for spatial light modulators\, mixed reality glasses\, head-on displays\, and microscopes\, and outline its potential biomedical applications. \n  \nBiography \nMaxim Shcherbakov is an assistant professor at UCI EECS. He was a postdoctoral associate with the School of Applied and Engineering Physics at Cornell University from 2016 to 2021. He received his M.S. and Ph.D. degrees in Physics from Lomonosov Moscow State University\, Russia. As a deputy group leader at Samsung Advanced Institute of Technology\, his research was focused on wearable electronics\, remote sensing\, and LiDARs. He is an author of more than 50 research papers and book chapters\, and recipient of awards in photonics\, telecommunications and nanotechnology. \n  \nREGISTER HERE
URL:https://bli.uci.edu/event/dr-maxim-r-shcherbakov-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2022/03/Maxim-R.-S.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220224T120000
DTEND;TZID=UTC:20220224T130000
DTSTAMP:20260823T103354
CREATED:20220214T211746Z
LAST-MODIFIED:20220214T214408Z
UID:30368-1645704000-1645707600@bli.uci.edu
SUMMARY:Dr. Dmitri Lapotko\, Ph.D.\, D.Sc.
DESCRIPTION:Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles \nAbstract\nTo improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer\, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale\, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event\, plasmonic nanobubble\, results from a novel physical-biological mechanism. Its mechanical impact was tuned to support cell level diagnostics\, drug release and intracellular injection of genetic or therapeutic payloads\, to enhance chemoradiation therapies in highly resistant and aggressive tumors\, to intraoperatively detect and destroy unresectable residual microtumors\, and to non-invasively detect bad actors\, all in personalized procedures with safe doses of nanoparticles and laser energies. Plasmonic nanobubble platform can be integrated with current or novel medical approaches to improve clinical outcomes where standards of care fail. \nBiography\nDmitri Lapotko obtained his MS in thermal physics and Ph.D. in laser applications from Belarus State University and Doctor of Science in bioengineering from Lyikov Heat and Mass Transfer Institute. His research in biophotonics and nanotechnology in basic\, applied and clinical science resulted in the invention of photothermal microscope for functional analysis of live cells\, laser-generated vapor nanobubbles (plasmonic nanobubbles) as a novel platform for diagnostic\, therapeutic and surgical technologies for cancer\, malaria and cardiovascular disease applications. \n  \nREGISTER HERE \n 
URL:https://bli.uci.edu/event/dr-dmitri-lapotko-ph-d-d-sc/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/02/Dmitri-Lapotko.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20211007T120000
DTEND;TZID=UTC:20211007T130000
DTSTAMP:20260823T103354
CREATED:20220608T191355Z
LAST-MODIFIED:20220608T191355Z
UID:30597-1633608000-1633611600@bli.uci.edu
SUMMARY:Quinton Smith\, Ph. D.
DESCRIPTION:Harnessing Physiological Forces to Drive Stem Cell Fate & Function \nAbstract\nI will be elaborating about how physical cues are crucial to embryonic development\, morphogenic events\, and tissue organization\, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues. As such\, the role of substrate stiffness\, fluid shear stress\, and confinement was interrogated on stem cell derived endothelial cell differentiation efficiency and functionality. We find priming hiPSCs on compliant substrates\, as opposed to traditionally used rigid plastic surfaces\, promotes efficient endothelial specification in the absence of growth factor supplementation. Leveraging micropatterned domains\, which restrict extracellular matrix accessibility\, also enhances endothelial specification and early lineage organization. Finally\, using a microfluidic platform\, we find that primary cilia\, a microtubule-based mechanosensor\, is crucial to stem cell derived endothelial shear response. Collectively\, we can investigate the role of biophysical stimuli on cell fate and function using a variety of engineering tools. \nBiography\nQuinton Smith is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Sue & Bill Gross Stem Cell Research Center\, Irvine. Quinton Smith received his bachelor’s degree from the University of New Mexico in\nchemical engineering and his Ph.D. in 2017 from Johns Hopkins University in chemical and biomolecular engineering. His predoctoral research was supported by an NIH/NHLBI F-31 and NSF Graduate Research Fellowship. Additionally\, he was named a Siebel Scholar in 2017. After completing his doctorate\, he trained as a Howard Hughes Medical Institute Hanna Gray Postdoctoral Fellow at the Massachusetts Institute of Technology. Dr. Smith joined the University of California Irvine in Spring 2021 and is currently an Assistant Professor in the Department of Chemical and Biomolecular Engineering and a member of the Sue Bill Gross Stem Cell Research Center. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/quinton-smith-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/06/Quinton_Smith.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20210923T120000
DTEND;TZID=UTC:20210923T130000
DTSTAMP:20260823T103354
CREATED:20220608T193312Z
LAST-MODIFIED:20220608T193312Z
UID:30609-1632398400-1632402000@bli.uci.edu
SUMMARY:Andy Shih\, Ph. D.
DESCRIPTION:Optical Dissection of Brain Capillary Function \nAbstract\nMy laboratory uses in vivo multiphoton imaging and rodent models to shed light (quite literally) on regulation of cerebral blood flow. In particular\, we have focused recent attention on the vast capillary networks that distribute blood throughout the brain. We use light to both visualize capillary structure and flow\, as well as noninvasively manipulate neurovascular cells that control capillary flow. We specialize in the application and development of in vivo multi-photon imaging approaches to study brain microvascular structure and function in rodents. Our recent findings include the construction of capillary networks during early postnatal development\, regulation of blood flow in adulthood by capillary pericytes\, and capillary changes in gray and white matter that may contribute to metabolic insufficiencies during aging and dementia. I firmly believe that our efforts will provide a unique and physiologically relevant view of microvascular function\, dysfunction\, and repair\, and will yield strategies for protecting vascular function in diseases that degrade the brain’s microvasculature. \nBiography\nAndy Shih is an Assistant Professor in the department of Developmental Biology & Regenerative Medicine at Seattle Children’s Research Institute. Additionally\, he is an assistant professor in the Department of Bioengineering and Department of Pediatrics at the University of Washington. His research focuses on optogenetic approaches to manipulate pericyte contractility in the intact brain\, and studies to delineate pathological features of mural cells in advanced age and small vessel disease. Shih earned a B.S. in Cell Biology and genetics from the University of British Columbia (2010) and Ph.D. in Neuroscience. He has completed his postdoc and been a project scientist from University of California\, San Diego (2012). Shih has been invited to several symposiums and been part of the SfN Nanosymposium chair (Stroke and Injury\, 2016) where he elaborates about his extensive findings & projects. A complete list of his published works in Google Scholar & NIH Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=andy+y+shih \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/andy-shih-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/06/shih.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20210729T120000
DTEND;TZID=UTC:20210729T130000
DTSTAMP:20260823T103354
CREATED:20220608T192629Z
LAST-MODIFIED:20220608T192629Z
UID:30605-1627560000-1627563600@bli.uci.edu
SUMMARY:Herdeline (Digs) Ardoña\, Ph. D.
DESCRIPTION:Hierarchical Strategies Towards Biointerfacing With Soft Optoelectronic Materials  \nAbstract\nThe applications of functional nanomaterials towards biological interfacing continue to emerge in various fields\, such as in drug delivery and tissue engineering. While the rational control of surface chemistry and mechanical properties have been achieved for several of these biocompatible systems\, these biomaterials are rarely synthesized with optical and electronic functionalities that could be beneficial for controlling the behavior of excitable cells (e.g.\, neurons and cardiac cells) or for biosensing applications. In this seminar\, I will first describe the development of one-dimensional peptidic nanostructures appended with organic electronic units\, which can facilitate photoinduced energy transfer under aqueous environments. These semiconducting peptide monomers that self-assemble as aligned hydrogels are successfully built according to design principles that allowed for directed photonic energy transport\, sequential electron transport in a multicomponent system\, and transmission or equilibration of voltage or current when incorporated in a transistor device. These soft scaffolding materials\, with tunable molecular to macroscale properties\, offer a unique tissue engineering platform that can locally and synergistically deliver electronic\, topographical\, and biochemical cues to cells. In the second part of the talk\, I will describe how to engineer in vitro models of cells and tissues which enables the understanding of nano-bio or abiotic-biotic interactions at multiple spatial scales. I will specifically describe physiologically relevant models that faithfully recapitulate the native form and function of cells or tissues involved in the systemic biodistribution of common nanomaterials—across biological barriers to target organs. These testing platforms were used to elucidate the dynamic structural and functional outcomes resulting from the exposure of vascular endothelium and myocardium to engineered nanomaterials. Finally\, this presentation will discuss the future applications of biopolymer assemblies with photonic and electronic functionalities as tools for controlling cellular processes and probing biophysical phenomena\, such as mechanotransduction and drug/toxicant permeation across tissues. \nBiography\nHerdeline Ann (Digs) M. Ardoña is originally from Valenzuela City\, Philippines. She received her B.S. in Chemistry (summa cum laude) from the University of the Philippines Diliman in 2011. In 2017\, she completed her Ph.D. in Chemistry at Johns Hopkins\, with funding support from Schlumberger Foundation and Howard Hughes Medical Institute. Her dissertation was focused on understanding the molecular design\, photophysical properties\, and supramolecular principles towards developing pi-conjugated peptide assemblies as bioelectronic nanomaterials. She then worked as a postdoctoral researcher in the Disease Biophysics Group at the Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences at Harvard University. As the 2018-2020 ACS Irving S. Sigal Postdoctoral Fellow\, she investigated the structural and functional impacts of multiple engineered nanomaterials through microphysiological platforms and biohybrid models. Digs started as an Assistant Professor at the UCI Department of Chemical and Biomolecular Engineering in Fall 2020. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/herdeline-digs-ardona-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/06/Ardona_Photo.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20210617T120000
DTEND;TZID=UTC:20210617T130000
DTSTAMP:20260823T103354
CREATED:20220608T192056Z
LAST-MODIFIED:20220608T192056Z
UID:30601-1623931200-1623934800@bli.uci.edu
SUMMARY:Philip Scumpia\, Ph. D.
DESCRIPTION:Translating an understanding of the cutaneous microenvironment into diagnostics and treatments for wounds\, cancers\, and inflammatory dermatoses \nAbstract\nImmune cells are the first responders to injury\, pathogens\, or malignancy. The various components of the tissue microenvironment dictate what immune cells do when they reach different tissues. The Scumpia lab studies how different components of the unique cutaneous microenvironment affect outcome following wounding\, bacterial infection\, or cancer. The overall goal is to develop an understanding of the cutaneous microenvironment regulates skin disease and to translate this knowledge into new diagnostics and therapies. \nBiography\nDr. Scumpia received a BS in Microbiology and Cell Sciences from the University of Florida. He received his M.D. and PhD. from the University of Florida where he studied the immunobiology of sepsis. He completed his residency and fellowship training in Dermatology and Dermatopathology at UCLA. He is currently an Assistant Professor in the Department of Medicine at UCLA where he studies how various components of the cutaneous microenvironment including nerves\, lipids\, and extracellular matrix\, regulate skin diseases. The goal is to translate this understanding into novel diagnostics and potential therapeutics. He is currently a member of the American Academy of Dermatology and the Society of Investigative Dermatology. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/philip-scumpia-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/06/Scumpia.jpg
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