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DTSTART;TZID=America/Los_Angeles:20220811T120000
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DTSTAMP:20260910T173134
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LAST-MODIFIED:20220811T163919Z
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SUMMARY:Olivia L. Lee\, MD
DESCRIPTION:  \nConfocal Microscopy for the Evaluation of OcularSurface Disease \nAbstract \nDiagnosis and treatment of ocular surface disease represents a large proportion of the average ophthalmologist’s\npractice. However\, this group of conditions is more heterogeneous and complex than the term “dry eye” conveys.\nFurther investigation of the pathophysiologic mechanisms underlying these conditions are underway\, and in vivo\nlaser scanning confocal microscopy (IVCM) has emerged as a suitable\, relatively novel\, minimally invasive tool for\nobtaining high-resolution images of tissues at the cellular level. Using this imaging device\, the in vivo visualization of\nthe human cornea can be employed to study ocular surface disease in a non-invasive manner. The use of IVCM\nprovides a new approach to evaluating the microscopic morphology of the cornea and our group has applied this to\nthe study of a variety of ocular surface diseases including Sjogrens syndrome\, Mucous Membrane Pemphigoid\, drug\ninduced dry eye\, Neurotrophic Keratitis\, Stevens Johnson Syndrome and more. IVCM is a promising technique for\nthe diagnosis\, prognostication\, staging and stratification of ocular surface disease. This talk will highlight the clinical\nand research applicability of this imaging technique as applied to ocular surface diseases. \n  \nBiography \nDr. Olivia L. Lee is a board-certified UCI Health ophthalmologist who specializes in corneal diseases and uveitis. Dr.\nLee received her medical degree from Baylor College of Medicine in Houston\, Texas\, followed by a residency in\nophthalmology from the New York Eye & Ear Infirmary in New York City\, where she also completed a fellowship in\nuveitis and ocular immunology. She completed a fellowship in cornea\, external disease and refractive surgery at the\nUCLA Stein Eye Institute. Before joining UCI Health\, she served as cornea fellowship director at the Doheny Eye\nCenter UCLA.\nDr. Lee’s research focuses on the use of anterior segment ophthalmic imaging to develop new clinical endpoints to\nobjectively characterize disease severity and guide clinical decision-making. Her clinical interests include\ninflammatory eye disease and complex anterior segment surgery. Dr. Lee has performed all types of corneal and\ncataract surgeries. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n 
URL:https://bli.uci.edu/event/olivia-l-lee-md/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/08/Olivia-Lee.jpg
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DTSTART;TZID=America/Los_Angeles:20220818T120000
DTEND;TZID=America/Los_Angeles:20220818T130000
DTSTAMP:20260910T173134
CREATED:20220811T162605Z
LAST-MODIFIED:20220811T163904Z
UID:30894-1660824000-1660827600@bli.uci.edu
SUMMARY:Jason B. King\, Ph. D.
DESCRIPTION:  \nLaser Beam Shaping for Surgery and Microbiopsy \nAbstract \nLasers are increasingly being used for surgery in a wide range of medical specialties due to their advantages over alternative\nsurgical tools. Advantages include precise material removal\, limited bleeding\, and delivery through optical fibers enabling use\nin body cavities and for minimally invasive surgeries. Advancements in laser technology including new laser wavelengths and\nhigher power continue to improve the performance and implementation of surgical lasers. Temporal beam shaping\, or pulse\nmodulation\, has been implemented into clinical laser systems to increase efficiency of urological surgeries\, leading to faster\,\nsafer procedures. However\, the precise mechanisms of temporally shaped laser ablation are not fully understood. The effects\nof spatial beam shaping on laser tissue ablation have not previously been explored.\nWe aim to understand the impact of temporal and spatial laser beam on laser ablation to improve the performance and\nincrease the applications of laser surgery. Working towards this aim\, a Ho:YAG laser was temporally and spatially altered and\nthe effects on tissue ablation were explored. We explored the mechanisms of pulse modulated ablation through experiments\non phantoms and native kidney stones. We discovered that increased ablation efficiency by pulse modulation is composition\ndependent. Next\, increased ablation efficiency by altering laser spatial shape was explored. We discovered that shaping the\nlaser beam into an annular shape led to an increase in ablation efficiency in both hard and soft tissues. Finally\, we explored\nthe application of spatially shaped laser ablation for laser microbiopsy to harvest sub-microliter (<1 mm3) tissue samples.\nLaser beam shaping\, pulse energy\, and application of cryogen spray cooling were optimized to successfully harvest tissue\nsections with observable histological features. Harvested tissues were imaged with confocal microscopy and “virtual H&E”\nmethods were used to digitally color the images to mimic H&E stained tissue sections. Laser microbiopsy with virtual H&E is\nminimally invasive\, precise\, and provides images in a fraction of the time of the traditional pathology workflow. \n  \nBiography \nDr. Jason King recently graduated with his PhD in biomedical engineering from the University of Texas at Austin. His work\nfocuses on optimization of laser ablation for surgery and biopsy through temporal and spatial laser beam shaping. This work\nincludes computational modeling and ablation experiments aimed at understanding light tissue interactions involved in laser\nablation. His other research interests include confocal microscopy and Raman spectroscopy for cancer diagnosis and\nmonitoring. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n 
URL:https://bli.uci.edu/event/jason-b-king-ph-d-2/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/08/Jasonbking.jpg
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