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X-WR-CALDESC:Events for Beckman Laser Institute
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DTSTART;TZID=UTC:20211202T120000
DTEND;TZID=UTC:20211202T130000
DTSTAMP:20260910T183804
CREATED:20211130T053721Z
LAST-MODIFIED:20211130T053721Z
UID:30060-1638446400-1638450000@bli.uci.edu
SUMMARY:Wenbin Tan\, Ph. D.
DESCRIPTION:Vasculopathy in COVID-19 and Pathogenesis of Cutaneous Vascular Malformations \nAbstract\nSARS-CoV-2-associated vasculopathy under hyperlipidemia and pathological progression of congenital vascular\nabnormalities in Port Wine Stains. In the first part\, we will present our clinical data for the first discovery of dyslipidemia\nin COVID-19 patients which have been substantially recognized. Mechanistically\, we have shown evidence of niche why\nobese subjects are more vulnerable to SARS-CoV-2 attack. Using a spike protein–pseudotyped (Spp) lentivirus with the\nproper tropism of the SARS-CoV-2 spike protein on the surface\, we have found that Spp lentiviruses preferably attack to\nendothelial cells in heart in obese but not normal weight mice\, leading to exaggerated vasculopathy and cardiomyopathy.\nCells with over-expression of Spike protein have impaired lipid metabolic and autophagy formation pathways\, resulting in\nincreased cell death in response to lipotoxicity. In the second part\, we will discuss the clinical molecular pathology of\ninfantile and early childhood PWS to show that (1) PWS is a disease with pathological alterations involving the entire skin\nphysiological milieu; (2) pluripotent cells with the GNAQ (R183Q) may give rise to multilineages in PWS; and (3) exocytosis\nof extracellular vesicles is enhanced in PWS vasculatures. \nBiography\nDr. Tan received his medical degree and master degree in Molecular Biology from XiangYa School of Medicine\, China. He\nreceived his PhD in neurobiology and neurophysiology from University of California\, Los Angeles. He joined Beckman\nLaser Institute at UC Irvine as an assistant project scientist in 2010 under the mentorship of Dr. Stuart Nelson. In 2018\,\nhe joined the department of cell biology and anatomy at School of Medicine University of South Carolina as an associate\nprofessor. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/wenbin-tan-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2021/11/Wenbin-Tan.jpg
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