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X-ORIGINAL-URL:https://bli.uci.edu
X-WR-CALDESC:Events for Beckman Laser Institute
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DTSTART:20180101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190404T120000
DTEND;TZID=UTC:20190404T130000
DTSTAMP:20260527T144537
CREATED:20190125T025111Z
LAST-MODIFIED:20190227T084914Z
UID:7423-1554379200-1554382800@bli.uci.edu
SUMMARY:Vincent Daria\, PhD
DESCRIPTION:Applied Physics\nFellow\, Group Leader (Neuro-photonics Group)\nANU College of Health and Medicine\nAustralian National University Canberra\, AU \n  \nUsing Complex Light Patterns To Understand Brain Circuits\nWe aim to understand how information is processed in cortical circuits of the mammalian brain.  To achieve this\, we use complex light patterns to stimulate and record the activity of single cortical neurons in a rat brain slice.  We use holographic projection of an ultrafast laser to produce multiple foci\, where each focus emulates a synaptic input or an optical recording probe. To emulate synaptic inputs\, multiple foci are directed onto spines of a neuron and gated illumination enables localized two-photon (2P) photolysis of caged neurotransmitters. Patterned spatio-temporal release of neurotransmitters onto multiple spines allows us to study the input-output characteristics of single neurons in the cortex. As an optical recording probe\, each focus excites neuronal activity reporters via 2P multi-foci excitation.  The fluorescence emanating from all foci are simultaneously recorded using an electron-multiplying charge-coupled device (EMCCD) camera thereby enabling simultaneous multi-channel recording of the neuronal activity from multiple sites.  We report recording of neuronal activity from two types of reporters: (1) calcium indicator\, Cal520; and (2) voltage indicator\, JPW1114.  We optically recorded the activity evoked by the neuron following injection of current onto the soma. Using this technique\, we have uniquely identified a crucial function of a specific set of dendrites for learning and memory. Moreover\, we can disable such function by prunning the specific dendrite via highly targetted femtosecond laser dendrotomy. Using complex light patterns to understand the input-output transfer function of single neurons enables bottom-up approach to understand information processing in the brain. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Daryl C Preece
URL:https://bli.uci.edu/event/vincent-daria-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/01/daria.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190327
DTEND;VALUE=DATE:20190401
DTSTAMP:20260527T144537
CREATED:20190127T000808Z
LAST-MODIFIED:20190201T024816Z
UID:7449-1553644800-1554076799@bli.uci.edu
SUMMARY:ASLMS 2019
DESCRIPTION:Hear why you can’t miss ASLMS 2019. \nDenver\, Colorado March 27 -31\, 2019. Visit http://www.aslms.org/annual-conference-2019 to register.
URL:https://bli.uci.edu/event/aslms-2019/
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2019/01/FPEFtfga_400x400.png
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190315T140000
DTEND;TZID=UTC:20190315T150000
DTSTAMP:20260527T144537
CREATED:20190221T063747Z
LAST-MODIFIED:20190221T064525Z
UID:20982-1552658400-1552662000@bli.uci.edu
SUMMARY:Xueding Wang\, Ph.D.
DESCRIPTION:Department of Biomedical Engineering\nDepartment of Radiology\nUniversity of Michigan School of Medicine \n  \nLight plus Sound: Imaging and Treatment\nPhotoacoustic imaging (PAI)\, also referred to as optoacoustic imaging\, is an emerging biomedical imaging technology that is noninvasive\, nonionizing\, with high sensitivity\, satisfactory imaging depth and good temporal and spatial resolution. Like conventional optical imaging\, PAI presents the optical contrast which is highly sensitive to molecular conformation and biochemical contents of tissues and can aid in describing tissue metabolic and hemodynamic changes. Unlike conventional optical imaging\, the spatial resolution of PAI is not limited by the strong light diffusion but instead determined by the measurement of light-generated ultrasonic signals. As a result\, the resolution of PAI is parallel to high-frequency ultrasonography. \nAt the University of Michigan School of Medicine\, our research has been focused on clinical applications of PAI\, including arthritis\, cancer\, liver conditions\, Crohn’s disease\, and eye diseases.  In this talk\, I will introduce some of our recently development of PAI technologies\, including 1) development of point-of-care PAI system for human inflammatory arthritis\, and 2) development of quantitative PAI for evaluating histological microfeatures and microenvironment of cancer. I will also present our recent development of a photoacoustic based anti-vascular technology named photo-mediated ultrasound therapy (PUT). Using a combination of a low intensity laser concurrently with ultrasound\, PUT can noninvasively remove microvessels without damaging surrounding biological tissue\, and shows potential to the treatment of a variety of diseases associated with neoangiogenesis\, such as age-related macular degeneration and diabetic retinopathy. \n  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. \nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/xueding-wang-ph-d/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Wang-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190220T123000
DTEND;TZID=UTC:20190220T133000
DTSTAMP:20260527T144537
CREATED:20190214T091649Z
LAST-MODIFIED:20190215T020121Z
UID:12372-1550665800-1550669400@bli.uci.edu
SUMMARY:Logan Swartz\, PhD
DESCRIPTION:Liu Group\, UC Davis \nScanning Probe Microscopy Based 3D Nanolithography\nThree dimensional (3D) printing has been an active area of research and development due to its capability to produce 3D objects by design.  Miniaturization and improvement of spatial resolution are major challenges in current 3D printing technology development.  This presentation reports advances in bringing 3D nanolithography to the nanometer scale using scanning probe microscopy (SPM).  SPM uses nanometer scale sharp tips to probe localized tip material interactions at the atomic and/or molecular level.  Taking advantage of the interactions to instead print materials\, in conjunction with SPM’s nanometer precision piezo based positioning systems and local surface chemistry\, we have been able to develop methods to advance 3D printing to 3D nanolithography/nanoprinting. \nThree methods were developed.  The first presented culminated in the first patented\, 3D nanoprinter.  It involves directly delivering polyelectrolyte complex materials layer-by-layer using an atomic force microscopy (AFM) probe.  This enabled creation of 3D nanostructures with nanometer precision in all three dimensions.  The second method describes development of a new technique for near-field scanning optical microscopy (NSOM) nanolithography.  NSOM lithography uses an SPM probe as a local light source to break the diffraction limit to perform photolithography.  We have created new versions of these probes by developing ways to attach fluorescent nanoparticles to the end of AFM probes.  The third method is a convenient way to modify with in situ control AFM probes to have a flat surface/plateau at their end.  These plateau probes\, mounted on an AFM\, are useful for compression studies to measure the created nanostructures’ nanomechanical properties. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Michael Berns
URL:https://bli.uci.edu/event/logan-swartz-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Logan-Swartz.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190219T100000
DTEND;TZID=UTC:20190219T110000
DTSTAMP:20260527T144537
CREATED:20190219T104205Z
LAST-MODIFIED:20190220T005029Z
UID:20146-1550570400-1550574000@bli.uci.edu
SUMMARY:Junle Qu\, Ph.D
DESCRIPTION:Professor of Optical Engineering\nShenzhen University \nSuper-resolution for live cell imaging\nSuper-resolution imaging has made remarkable progress in recent years\, providing a powerful tool for biology. It allows for the observation of fine structures of cells\, cellular dynamics and cellular functions at nanometer scale or even single molecular level\, which greatly promotes the development of life science and many other fields. In this talk I will present our recent work in super-resolution optical microscopy. By combining stimulation emission depletion (STED) microscopy and fluorescence lifetime imaging (FLIM)\, we can improve the spatial resolution of STED and perform FLIM imaging at nanometer resolution. Novel fluorescent probes with low STED laser power and experiment strategies were designed for live cell mitochondria imaging. Coherent adaptive optical technique (COAT) has been implemented in STED microscope to circumvent the scattering and aberration effect for thick sample imaging. Stochastic optical reconstruction microscopy (STORM) superresolution imaging of mitochondrial membrane in live cells was achieved by the development of new fluorescent probes\, improved imaging system and optimized single molecule localization algorithm. These developments make it possible to study dynamic events and complex functions in living cells\, even with a single conventional microscope. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/junle-qu/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Junle-Qu.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190208T120000
DTEND;TZID=UTC:20190208T130000
DTSTAMP:20260527T144537
CREATED:20190202T034746Z
LAST-MODIFIED:20190202T042038Z
UID:7530-1549627200-1549630800@bli.uci.edu
SUMMARY:Inga Saknite\, PhD
DESCRIPTION:Vanderbilt Translational Skin Imaging Clinic\nVanderbilt University Medical Center \nLeukocyte dynamics in human skin capillaries by noninvasive reflectance confocal microscopy\nInflammatory tissue response is one of the first and most common manifestations of acute graft-versus-host disease (aGVHD)\, a potentially deadly immune-mediated disease that occurs in 30-60% of patients after hematopoietic stem cell transplantation. A fundamental challenge in developing effective treatment strategies for aGVHD is the lack of tools to study disease biology in real-time in post-transplant patients. The inflammatory tissue response causes increased expression of specialized endothelial proteins on vessel walls making leukocytes to roll\, adhere and eventually extravasate into the tissue at a higher rate than in normal conditions. Although the importance of leukocyte-endothelial interactions to detect and track inflammation has been well shown in murine models\, there are no published clinical studies in humans. In this study\, we explore the feasibility to detect presence of aGVHD in post-transplant patients through the imaging of in vivo leukocyte motion. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Mihaela Balu
URL:https://bli.uci.edu/event/inga-saknite/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/inga.jpg
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