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X-WR-CALDESC:Events for Beckman Laser Institute
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DTSTART:20190101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190812T120000
DTEND;TZID=UTC:20190812T130000
DTSTAMP:20260420T031939
CREATED:20190724T062243Z
LAST-MODIFIED:20190724T062446Z
UID:27290-1565611200-1565614800@bli.uci.edu
SUMMARY:Thomas O’Sullivan\, PhD
DESCRIPTION:Assistant Professor\, Department of Electrical Engineering\, University of Notre Dame \nFast-Changing Times: Advanced Optical Technologies Enabling the Next Generation of Quantitative Diffuse Optical Spectroscopy \nAbstract\nQuantitative Noninvasive Diffuse Optical Spectroscopy utilizing time-dependent methods can separate the effects of optical absorption and scattering and thus provide greater accuracy\, precision\, and 3D resolution of deep tissue physiology compared to continuous-wave methods.  Unfortunately\, despite 30 years of research demonstrating its utility in a myriad of clinical applications (e.g. cancer\, neuroscience\, critical care\, metabolic disease\, etc.)\, time-dependent methods are complex\, bulky\, and expensive. This has resulted\, at best\, in slowed clinical adoption and\, at worst\, distrust of the technology itself. In order to overcome these barriers\, our group researches new optical components and techniques for diffuse optical spectroscopy that are leading to a new generation of handheld\, wearable\, and even implantable systems.  This will facilitate the conversion of advanced time-dependent imaging methods to accessible compact systems that will drive widespread use in biomedical sensing and imaging. \nBiography\nDr. Thomas O’Sullivan has been an assistant professor in the Department of Electrical Engineering at the University of Notre Dame since 2016. Prior to that he was Director of the Diffuse Optical Spectroscopy and Imaging Laboratory at the Beckman Laser Institute of the University of California\, Irvine and a U.S. Department of Defense Breast Cancer Research Program Postdoctoral Fellow. He received the B.S. degree in Electrical Engineering from Northwestern University in 2005 and the M.S. and Ph.D. in Electrical Engineering from Stanford University in 2007 and 2011\, respectively. Dr. O’Sullivan is engaged in translational biomedical research based upon the development and application of deep tissue optical imaging and sensing. In addition to his research\, Dr. O’Sullivan is passionate about community outreach\, has served the optics and photonics community through multiple volunteer roles for OSA and SPIE\, and is currently an associate editor for Biomedical Optics Express.  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/thomas-osullivan-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/07/Thomas-OSullivan-192.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190808T120000
DTEND;TZID=UTC:20190808T130000
DTSTAMP:20260420T031939
CREATED:20190711T015248Z
LAST-MODIFIED:20190711T015324Z
UID:27268-1565265600-1565269200@bli.uci.edu
SUMMARY:Lida Hariri\, MD\, PhD
DESCRIPTION:Assistant Professor\,  Department of Pathology\nDivision of Pulmonary and Critical Care Medicine\nMassachusetts General Hospital\, Harvard Medical School \nIn Vivo Optical Coherence Tomography for Early Detection and Diagnosis of Pulmonary Disease \nAbstract\nIn vivo optical imaging provides microscopic images in patients\, in real time\, without tissue removal. Due to its high resolution\, optical imaging has close parallels with traditional microscopy and can complement and enhance patient care\, including in vivo disease detection\, biopsy guidance\, diagnosis\, and resection margin assessment\, in a variety of organ systems and disease types. In this talk\, I will discuss applications of optical coherence tomography for early detection and diagnosis of pulmonary diseases\, particularly lung cancer and interstitial lung disease\, and real-time tumor biopsy guidance to increase diagnostic yield. \nBiography\nLida Hariri\, MD\, PhD\, is an Assistant Professor of Pathology and biomedical optics researcher at Massachusetts General Hospital. She obtained her MD/PhD at the University of Arizona in 2009\, with her doctorate in Biomedical Engineering focused on multimodal optical imaging for early cancer detection. She subsequently completed her pathology residency training\, and pulmonary and gynecologic pathology fellowships at MGH. Her research interests focus on development\, translation and clinical application of high-resolution optical imaging for: 1) early detection and diagnosis of pulmonary diseases\, particularly lung cancer and interstitial lung disease\, 2) real-time tumor biopsy guidance to increase diagnostic yield\, and 3) integrating in vivo optical microscopy into the practice of clinical medicine and pathology. She is a Vice-Chair of the College of American Pathologists (CAP) In Vivo Microscopy Committee.   \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/lida-hariri-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/07/Hariri_Lida_192.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190722T120000
DTEND;TZID=UTC:20190722T130000
DTSTAMP:20260420T031939
CREATED:20190704T032500Z
LAST-MODIFIED:20190704T033712Z
UID:22042-1563796800-1563800400@bli.uci.edu
SUMMARY:Liangzhong (Shawn) Xiang\, PhD
DESCRIPTION:Assistant Professor of Electrical and Computer Engineering at University of Oklahoma \nStephenson Cancer Center at University of Oklahoma Health Sciences Center \nX-ray-induced Acoustic Computed Tomography (XACT) \nAbstract\nX-ray computed tomography (CT) has proved tremendously useful for noninvasive medical imaging ever since its inception nearly 50 years ago. However\, there remain two major limitations: radiation harm and inaccessibility to patient.\nIn 2013\, for the first time\, we reported a novel x-ray imaging modality\, x-ray induced acoustic computed tomography (XACT)\, to overcome these limitations of conventional x-ray CT imaging. In XACT\, pulsed x-ray excitation of a sample results in localized heating\, and subsequent thermoelastic expansion\, for sufficiently short-lasting pulses\, this results in the emission of a detectable acoustic wave in the ultrasound regime\, with amplitude proportional to x-ray absorption. This unique hybrid imaging modality combines high x-ray absorption contrast with the 3D propagation advantages provided by high resolution encoding ultrasound waves. XACT imaging shows potential to produce a 3D volumetric image from a single X-ray projection. Thus\, XACT can dramatically reduce radiation dose and improve imaging speed as compared to conventional x-ray CT with hundreds of projections. Moreover\, XACT imaging also requires only single-side access to the patient versus traditional X-ray imaging’s requirement for access to two opposing sides of the patient. We expect our work may profoundly advance X-ray imaging technology.\nMy main research interest is in developing XACT imaging and enable its clinical translation. I will present a wide range of applications of XACT ranging from radiation oncology (in vivo dosimetry for external radiotherapy on breast cancer and prostate cancer)\, to radiological imaging (breast microcalcification\, bone tumor\, and osteoporosis). \nBiography\nDr. Liangzhong Xiang is an Assistant Professor in the Department of of Electric and Computer Engineering\, and Stephenson Cancer Center at University of Oklahoma (OU). Dr. Xiang received his Ph.D. degree from South China Normal University on photoacoustic molecular imaging. He was a postdoctoral fellow trained in medical physics at Stanford Medical School\, and he awarded the U.S. Department of Defense (DoD) Prostate Cancer Postdoctoral Training Program at Stanford University (2012-2015).\nIn research\, Dr. Xiang and his laboratory was the first to report x-ray-induced acoustic computed tomography (XACT). His work on XACT imaging was the cover article for Medical Physics in 2013. His talk entitled “X-ray acoustic computed tomography: concept and design” has been identified as a “Hot Topic” presentation for the 2013 AAPM Annual Meeting. And he received the Slvia Sorkin Greenfield Award for the best paper of the Medical Physics at AAPM 50th Annual Meeting.  His research has led to over 60+ peer-reviewed publications\, 12 patents\, 30+ presentations. Sponsored by NIH\, DoD and Oklahoma state funding agencies with over $ 3 million dollars active grant support. In education\, he received Nancy L. Mergler Faculty Mentor Award for Undergraduate Research (the only recipient at OU in 2017). He strategically guides lab students to become extraordinary and independent scientists. His students have been awarded SPIE Education Scholarship (2019\, 2018)\, SPIE Travel Scholarship (2016). His postdoctoral research fellows were awarded the Trainee Research Prize from the Radiological Society of North America (RSNA\, 2015). In service\, Dr. Xiang has served as conference chairs in AAPM annual meeting (2019) and International Conference on Information Optics and Photonics (CIOP 2018)\, SPIE Student Chapter advisor\, associate editor of Medical Physics journal\, and grant reviewer for U S Department of Energy\, Russian Science Foundation (RSF)\, and Helmholtz Association of German Research Centre. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/liangzhong-xiang-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/07/Liangzhong-Xiang.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190718T120000
DTEND;TZID=UTC:20190718T130000
DTSTAMP:20260420T031939
CREATED:20190704T033854Z
LAST-MODIFIED:20190704T034318Z
UID:22051-1563451200-1563454800@bli.uci.edu
SUMMARY:Bahman Anvari\, PhD
DESCRIPTION:Professor\, Department of Bioengineering\, UC Riverside \nCancer Photo-Theranostics \nAbstract\nNano-sized structures provide a platform for the delivery of imaging and therapeutic agents to tumors. When activated by light\, these structures enable visualization of small tumor nodules and their destruction through a variety of photo-transduction mechanisms. My lab focuses on the engineering of nano-sized platforms derived from biological materials\, including erythrocytes\, and their translation for cancer photo-theranostics. In this talk\, I will present some of the photophysical properties of these constructs when doped with near infrared chromophores\, and show their capabilities in targeted fluorescence molecular imaging of important cancer cell biomarkers and photo-destructions of tumor implants in animal models. I will also discuss some of the considerations necessary for clinical translation of these structures in a safe manner.     \nBiography\nBahman Anvari is a Professor in the Department of Bioengineering at UC Riverside\, and holds courtesy appointments in the Departments of Biochemistry\, and Mechanical Engineering\, and Biophysics and Biomedical Sciences Graduate Programs at UCR. He received his B.A. in Biophysics from UC Berkeley\, and Ph.D. in Bioengineering from Texas A&M University. He was a Postdoctoral Researcher at the Beckman Laser Institute\, and started his faculty career as an Assistant Professor in the Department of Bioengineering at Rice University where he became an Associate Professor.\nDr. Anvari’s scientific interests include the development and application of optical probes for biomedical imaging and therapeutic purposes. He is a co-inventor on some of the patented technologies related to the dynamic cooling of human skin.  His research activities have been continuously funded by NIH\, NSF\, and other agencies. He has published over 300 peer-reviewed and conference papers. Dr. Anvari served as an Associate Editor for the Annals of Biomedical Engineering for nearly ten years\, and is currently an Editorial Board Member of Journal of Biomedical Optics. Professor Anvari is a Fellow of American Institute for Medical and Biological Engineering (AIMBE)\, American Association for the Advancement of Science (AAAS)\, Biomedical Engineering Society (BMES)\, and the International Society for Optics and Photonics (SPIE). He is the 2019 recipient of the Caroline & William Mark Memorial Award by the American Society for Laser Medicine & Surgery (ASLMS)\, and currently serves as the Basic Science Representative at ASLMS Board. Dr. Anvari is the founder of Radoptics\, LLC\, a start-up company interested in commercialization and translation of cell-derived optical probes. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/bahman-anvari-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/07/Anvari.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190710T120000
DTEND;TZID=UTC:20190710T130000
DTSTAMP:20260420T031939
CREATED:20190612T010718Z
LAST-MODIFIED:20190704T032053Z
UID:21570-1562760000-1562763600@bli.uci.edu
SUMMARY:Ghazal Azarfar\, Ph.D.
DESCRIPTION:Research Assistant at the Laboratory for Surface studies\, University of Wisconsin\, Milwaukee \nLight Scattering in Diffraction Limit Infrared Hyperspectral Imaging\nAbstract\nFourier Transform Infrared (FTIR) microspectroscopy is a noninvasive technique for chemical imaging of micrometer size samples. Employing an infrared source\, a microscope coupled to a FTIR spectrometer\, and replacing a single detector with an array of detectors (128 x 128 detectors) enables collecting combined spectral and spatial information simultaneously\, resulting in wavelength dependent images which\, are being used for disease pathology and cell cycle study. In this research we are trying to remove one of the last technological barriers to the development of clinical spectroscopic cytology.\nIn diffraction limit FTIR imaging\, where the size of the sample is in the same range as the incident light\, scattering phenomenon appear in spectra as a result of the interaction of the light and matter. The observed scattering contribution dependents physical and chemical structure of the sample as well as the focusing optic and the light source. A new optimization method for correcting the scattering phenomena in pixelated infrared spectra and recovering wavelength dependent complex refractive of the sample using holographic phase images will be presented. \nBiography \nDr. Ghazal Azarfar has defended her PhD thesis in Electrical Engineering in June 2019.  She is currently working as a research assistant at the Laboratory for Surface Studies at University of Wisconsin Milwaukee (UWM). She is the president of the society for applied spectroscopy at UWM\, and has received multiple awards including the Four-Year Dean’s fellowship award\, Chancellor’s award  and Honorable Mention award. She has published a paper on Fourier transform infrared imaging of a single live cell. The focus of her research is scattering correction in the diffraction limit hyperspectral infrared imaging. Her research resulted in a new algorithm for 3D reconstruction of holographic images. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/ghazal-azarfar/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/Ghazal-Azarfar.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190709T120000
DTEND;TZID=UTC:20190709T130000
DTSTAMP:20260420T031939
CREATED:20190627T043107Z
LAST-MODIFIED:20190629T032737Z
UID:21882-1562673600-1562677200@bli.uci.edu
SUMMARY:Toyohiko Yamauchi
DESCRIPTION:Associate Researcher at the Beckman Laser Institute\, UC Irvine \nQuantitative Phase Microscopy for the Evaluation of Cell Morphological Properties\nAbstract\nCell morphology and dynamics are related to a variety of significant biomedical properties\, such as the metastatic potential of cancer cells\, disease related stiffness changes in red blood cells\, pluripotency of stem cells\, and cell-to-cell interactions by tunneling nanotubules. Phase contrast microscopes or differential interference contrast microscopes are the most popular methods to evaluate the morphological features of live cells\, but these methods are not quantitative nor reproducible between different models of microscopes. For these reasons\, there has been a push to develop and validate more quantitative microscopy techniques\, such as Quantitative Phase Microscopy (QPM). QPM is an interferometry-based technique which measures the optical thickness of cells. Optical thickness is a well-defined physical property and can be used to obtain quantitative and reproducible thickness mapping of live cells within a clear background. By means of the image processing on optical thickness\, QPM enables the tracing of cell boundaries and the quantification of vectors of membrane motion. Moreover\, QPM does not require fluorescence dye (label free) and it enables long term\, time-lapse imaging of live cells for more than 48 hours. In this talk\, Toyohiko Yamauchi will introduce the theory of QPM and detail his efforts in designing\, building\, and testing QPM instruments.\nToyohiko installed his latest QPM prototype in the Beckman Laser Institute in February 2018 and has been building new research collaborations throughout UCI to develop new applications. In the latter half of this seminar\, several active collaborators will also talk about ongoing and future studies with QPM. \nBiography\nToyohiko Yamauchi graduated from the University of Tokyo with undergraduate and master’s degrees in electrical engineering. Toyohiko has been an application researcher of optical interferometry for Hamamatsu Photonics (Japan) for more than 10 years. From 2008 to 2010\, Toyohiko worked as a visiting scientist with Dr. Michael S. Feld at the MIT-Laser Biomedical Research Center to develop his quantitative phase microscope. After returning to Japan\, Toyohiko joined a government sponsored New Energy and Industrial Technology Development Organization (NEDO) project for low-invasive quality assessment of induced pluripotent stem cells from 2011 to 2014. Since then\, Toyohiko has been collaborating with biologists in both the US and in Japan for application development of QPM and he most recently spent 18 months at UCI as a visiting researcher. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/toyohiko-yamauchi/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2018/12/ToyohikoYamaychi.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190708T120000
DTEND;TZID=UTC:20190708T130000
DTSTAMP:20260420T031939
CREATED:20190618T055844Z
LAST-MODIFIED:20190618T060334Z
UID:21585-1562587200-1562590800@bli.uci.edu
SUMMARY:Mihaela Balu\, Ph.D.
DESCRIPTION:Associate Researcher at the Beckman Laser Institute\, UC Irvine \nClinical skin imaging with multiphoton microscopy– current strategies and future directions \nAbstract\nThe ability of multiphoton microscopy (MPM) to generate high-resolution 3D maps of specific tissue molecular compounds led to its widespread use in biomedical applications. MPM has been successfully employed in research labs for basic biology studies and imaging of small animal models but due to the complexity and cost of the microscope systems\, only recently it started to be explored as a technique for non-invasive in-vivo human skin imaging. In the US\, the first clinical skin imaging research studies using MPM have been initiated at BLI by our group in collaboration with the Dermatology Department at UCI using the first commercial clinical MPM system. Since 2012\, ~300 patients have been enrolled in our research studies. In this talk\, I will present results from several MPM clinical studies\, with an emphasis on our most advanced research on quantitative imaging for non-invasive early diagnosis of melanoma. Other applications include employing in vivo MPM for guiding treatment of pigmentary skin disorders and monitoring the re-pigmentation process of skin disorders such as vitiligo. These applications have been driven by novel MPM developments. In the same time\, they are driving further advances of the technology to address current barriers\, such as limited scanning area and scanning speed. I will present an overview of the current stage of development of our proposed clinical MPM platform for skin imaging that addresses these limitations\, while offering enhanced portability and reduced complexity. I will also discuss the challenges involved in the translational process of this technology and potential approaches to overcome them\, along with strategies for integrating advanced imaging with artificial intelligence-based diagnostic algorithms and with single cell transcriptomics to capture the cellular\, molecular and metabolic signatures in tissues of interest. \nBiography\nMihaela Balu\, Ph.D.\, is Associate Researcher at the Beckman Laser Institute\, UC Irvine. She has a Master in Physics and a PhD in Optics from the College of Optics and Photonics (CREOL)\, University of Central Florida. Her research is focused on integrating and advancing modern biophotonics technologies such as nonlinear optical microscopy to clinical setting. Her main goal is to use this technique as a non-invasive imaging tool for visualizing\, quantifying and understanding the morphological and underlying molecular processes in skin\, with a particular interest in melanoma and non-melanoma skin cancer. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/mihaela-balu-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/Mihaela-Balu.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190702T120000
DTEND;TZID=UTC:20190702T130000
DTSTAMP:20260420T031939
CREATED:20190613T053318Z
LAST-MODIFIED:20190613T053318Z
UID:21581-1562068800-1562072400@bli.uci.edu
SUMMARY:Stefan Carp\, PhD
DESCRIPTION:Assistant Professor of Radiology at Harvard Medical School \nNon-invasive Biophotonics for Personalized Medicine\nAbstract\nPersonalized or precision medicine is an emerging paradigm in health care delivery that seeks to tailor medical treatment to the individual characteristics\, needs and preferences of each patient. Biophotonic technologies are likely to play a significant role in realizing the benefits of personalized medicine by leveraging novel contrast mechanisms to offer timely feedback on treatment progress\, and can be integrated into compact\, cost-effective devices that are suitable for longitudinal patient monitoring.\nOur work has been focused on the technology development and clinical translation of optical imaging and sensing using near-infrared light. This talk will report on our efforts in two major application areas:  in the context of breast cancer management\, we are combining dynamic diffuse optical tomography with x-ray digital breast tomosynthesis to improve breast cancer diagnosis and neoadjuvant chemotherapy monitoring outcomes; in the context of neuromonitoring\, we are advancing methods for the accurate quantification of brain health in the presence of systemic physiology interference in adults\, by using a combination of near-infrared spectroscopy and diffuse correlation spectroscopy techniques together with advanced light transport models\, with the goal to offer new tools for improving the management of brain perfusion in patients undergoing cardiovascular interventions. \nBiography\nDr. Stefan Carp is an Assistant Professor of Radiology at Harvard Medical School and a member of Massachusetts General Hospital Martinos Center Optics Division. He received his BS degrees in chemistry and chemical engineering from MIT and pursued his doctorate at U.C. Irvine (UCI) under the supervision of Dr. Vasan Venugopalan. At UCI he discovered the field of biomedical optics and developed a non-contact optoacoustic imaging system for his dissertation project. After graduation\, he worked on optical breast imaging after moving to the Massachusetts General Hospital\, where he now leads a research group that focuses on the development of novel techniques for tissue hemodynamics and oxygen metabolism monitoring to help advance personalized medicine. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/stefan-carp-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/CARP.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190701T120000
DTEND;TZID=UTC:20190701T130000
DTSTAMP:20260420T031939
CREATED:20190613T052528Z
LAST-MODIFIED:20190613T052528Z
UID:21577-1561982400-1561986000@bli.uci.edu
SUMMARY:Nicholas J. Durr\, Ph.D.
DESCRIPTION:Assistant Professor of Biomedical Engineering\, Johns Hopkins University \nDesigning Solutions to Healthcare Needs With Computational Biophotonics\nAbstract\nComputational biophotonics pairs optical system design with the development of intelligent algorithms to extract meaningful data from interrogated tissues (often via an unintuitive computational image). With the recent dramatic advances in deep learning tools\, there are many exciting opportunities to apply data-driven models with novel imaging systems to create impactful medical devices. I will present our efforts in developing and translating computational biophotonics medical devices for a variety of important healthcare needs\, including: (1) improving the management of colorectal cancer with deep learning and the computational colonoscope\, (2) enabling a non-invasive blood count with gradient-field capillaroscopy\, and (3) making eye care more accessible with a low-cost\, handheld wavefront aberrometer. \nBiography\nNicholas Durr is an Assistant Professor of Biomedical Engineering at Johns Hopkins University and the co-Director of Undergraduate Programs at the Center for Bioengineering Innovation and Design (CBID). He received a B.S. in Electrical Engineering and Computer Science from U.C. Berkeley in 2003\, worked as a Research Engineer at Nellcor from 2003 to 2004\, and received a Ph.D. in Biomedical Engineering from U.T. Austin in 2010. He completed a Postdoctoral Fellowship at Harvard Medical School in 2011 and was an independent investigator at MIT from 2011 to 2014 as a Fellow in the M+Visión Consortium. In 2013 he co-founded PlenOptika\, which he led as CEO until he joined Hopkins in 2016.  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/nicholas-durr-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/NDURR.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190613T120000
DTEND;TZID=UTC:20190613T130000
DTSTAMP:20260420T031939
CREATED:20190603T230251Z
LAST-MODIFIED:20190603T231717Z
UID:21541-1560427200-1560430800@bli.uci.edu
SUMMARY:Anand Kumar\, PhD
DESCRIPTION:Assistant Professor\, Harvard Medical School\nAssistant Professor\, Massachusetts General Hospital\, Boston \nBiological imaging with time domain fluorescence\nAbstract\nMolecular imaging combines the use of disease targeted contrast agents with advanced imaging techniques to visualize disease processes in whole living organisms from the small animal to the human scale. Optical techniques are emerging as promising tools for molecular imaging by providing functional contrast\, and are particularly attractive given the spectral and fluorescence lifetime tunability of near infrared fluorophores. This allows the exciting possibility of multiplexing using fluorescence spectral and lifetime contrast. \nMy laboratory is focused on the development and application of whole-body time domain imaging techniques\, with emphasis on exploiting lifetime contrast for enhanced sensitivity and specificity of disease detection in vivo.  Although fluorescence lifetime imaging has been widely used in microscopy using fluorescence lifetime imaging (FLIM)\, the application of lifetime imaging for macroscopic subjects has been limited by several challenges.  This presentation will outline some of these challenges and how they can be addressed using theoretical and experimental methods for time domain imaging.  In particular\, I will discuss a novel algorithm for tomographic lifetime multiplexing which allows the complete separation and 3-D localization of multiple lifetimes simultaneously present within biological tissue. Recent extensions of this work to the spatial frequency domain using modulated sources will also be discussed. I will then present in vivo applications of the technology pertaining to cancer and cardiac disease models. I will finally discuss our recent progress towards clinical applications of fluorescence lifetime imaging for cancer detection. \nBiography\nAnand Kumar is an Assistant Professor at Harvard Medical School and the Massachusetts General Hospital in Boston.  Dr. Kumar received his M.Sc. from the Indian Institute of Technology\, Chennai\, India and Ph. D. from Northeastern University\, Boston\, both in Physics. Following his doctoral work on ultrafast laser spectroscopy\, he worked in Sycamore Networks as a Senior Optical Engineer for 2 years\, where he designed commercial fiber optic networks. Subsequently\, he moved to the Athinoula A. Martinos center in 2002 as a post-doctoral fellow and joined the faculty of the center as an Instructor in 2007 and Assistant Professor in 2012. His current research focus is on preclinical and clinical applications of diffuse optical tomography and optical molecular imaging\, with particular emphasis on time domain imaging techniques. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/anand-kumar-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/ANAND-KUMAR-192.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190610T120000
DTEND;TZID=UTC:20190610T130000
DTSTAMP:20260420T031939
CREATED:20190530T230819Z
LAST-MODIFIED:20190604T034800Z
UID:21528-1560168000-1560171600@bli.uci.edu
SUMMARY:Anita Mahadevan-Jansen\, PhD
DESCRIPTION:Professor of Biomedical Engineering at Vanderbilt University  \nProblem-based research shortens the pathway to to clinical translation of light-based technologies\nAbstract\nMedicine is a problem rich environment where there is a critical need for new solutions that ease the life of the patient\, the physician and the caregiving staff. For at least some of these problems\, biophotonics could well be the answer! Optical techniques can be used to provide real-time assessment for screening\, diagnosis\, monitoring and guidance of therapy. In this presentation – I will discuss 2-3 different medical challenges and the optical solution that was developed and implemented in a clinical setting. These examples include the application of near infrared fluorescence imaging for the anatomical detection of the parathyroid gland during endocrine surgery and in vivo biochemical characterization of the pregnant human cervix towards understanding preterm birth.  \nBiography\nDr. Mahadevan-Jansen translates optical techniques for clinical detection of tissue physiology and pathology. Her primary research at the Vanderbilt Biophotonics Center\, is to investigate the applications of optical spectroscopies and imaging for disease diagnosis and guidance of therapy. She received her bachelor’s and master’s degrees in Physics from the University of Bombay (Mumbai)\, India\, and a master’s and PhD degrees in Biomedical Engineering from the University of Texas at Austin. She joined the Vanderbilt engineering faculty in 1996. She is currently the Orrin H. Ingram Professor of Biomedical Engineering at Vanderbilt University and holds a secondary appointment in the Departments of Neurological Surgery and Otolaryngology. She is the founding Director of the Vanderbilt Biophotonics Center\, the Director of the Vanderbilt branch of the Center for Integration of Research in Teaching and Learning (CIRTL)\, an NSF funded 46-institution center as well as Director of Undergraduate Studies for the Department of Biomedical Engineering at Vanderbilt University.\nShe is currently on the Board of Directors of the International Society for Optical Engineering (SPIE) and is a fellow of SPIE\, Optical Society of America (OSA) as well as the American Institute of Medical and Biological Engineering (AIMBE). \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/anita-mahadevan-jansen-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/anita.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190606T123000
DTEND;TZID=UTC:20190606T133000
DTSTAMP:20260420T031939
CREATED:20190521T230028Z
LAST-MODIFIED:20190524T004017Z
UID:21481-1559824200-1559827800@bli.uci.edu
SUMMARY:Joseph A. Izatt\, PhD
DESCRIPTION:Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering\nProfessor of Ophthalmology\, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University \nNew Optical Technologies for Real-Time Biomedical Imaging and Image-Guided Surgery\nAbstract\nCutting edge optical biomedical imaging technologies adaptively control optical wavefronts and exploit spatial and temporal coherence to obtain wavelength-scale measurements of structure and function inside living biological tissues\, while leveraging optical communications bandwidths to enable real-time 3D imaging. We have developed implementations of these technologies for multiple applications including super-resolved non-invasive retinal imaging\, flexible hand-held interactive clinical diagnostic imaging\, and real-time intrasurgical visualization and operative guidance. These advances allow for continuous volumetric microstructural imaging in living patients\, and extend the benefits of the latest imaging technologies to previously inaccessible patient populations. Using these tools\, we have demonstrated live imaging of individual retinal receptor cells both with and without adaptive optics\, including the first demonstrations of retinal cone cell imaging in infants and children. We have pioneered the integration of optical coherence tomography into ophthalmic microsurgery\, including surgical microscope-integrated image acquisition\, real-time augmented reality visualization\, and image-guided tele-operative and cooperative robotic manipulation of surgical tools with micrometer-scale precision. Several of these technologies have accomplished the transition from basic research\, to clinical trials\, to wide-scale adoption and commercial success\, and thus serve as useful examples of the accumulating impact and continuing importance of innovation in biomedical optics and biophotonics.  \nBiography\nJoseph A. Izatt is the Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering\, Professor of Ophthalmology\, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University. Prof. Izatt’s research interests include biomedical optics and spectroscopy\, coherence-based and wavefront-optimized tomographic optical imaging\, and novel instrumentation for intrasurgical visualization and manipulation. He has authored over 200 peer-reviewed publications\, more than 350 contributed and 130 invited lectures and presentations\, and more than 70 issued patents\, which altogether have accumulated over 38\,000 citations. Izatt was the founding Editor-In-Chief of Biomedical Optics Express\, OSA’s principle outlet serving the biomedical optics community\, and has co-chaired the leading annual conference in Optical Coherence Tomography (at SPIE’s Photonics West) for two decades. Professor Izatt has worked with multiple companies to license commercial technologies related to optical biomedical imaging\, including co-founding Bioptigen\, Inc.\, which was acquired by Leica Microsystems in 2015. Dr. Izatt is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, The International Society for Optics and Photonics (SPIE)\, The Optical Society (OSA)\, and the National Academy of Inventors (NAI). \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/joseph-a-izatt-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/Izatt.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190603T120000
DTEND;TZID=UTC:20190603T130000
DTSTAMP:20260420T031939
CREATED:20190530T222905Z
LAST-MODIFIED:20190603T232041Z
UID:21513-1559563200-1559566800@bli.uci.edu
SUMMARY:Xueding Wang\, Ph.D.
DESCRIPTION:Department of Biomedical Engineering\nDepartment of Radiology\nUniversity of Michigan School of Medicine \nLight plus Sound: Photoacoustic Imaging and Treatment\nAbstract\nPhotoacoustic imaging (PAI)\, also referred to as optoacoustic imaging\, is an emerging biomedical imaging technology that is noninvasive\, nonionizing\, with high sensitivity\, satisfactory imaging depth and good temporal and spatial resolution. Like conventional optical imaging\, PAI presents the optical contrast which is highly sensitive to molecular conformation and biochemical contents of tissues and can aid in describing tissue metabolic and hemodynamic changes. Unlike conventional optical imaging\, the spatial resolution of PAI is not limited by the strong light diffusion but instead determined by the measurement of light-generated ultrasonic signals. As a result\, the resolution of PAI is parallel to high-frequency ultrasonography. \nAt the University of Michigan School of Medicine\, our research has been focused on clinical applications of PAI\, including arthritis\, cancer\, liver conditions\, Crohn’s disease\, and eye diseases.  In this talk\, I will introduce some of our recently development of PAI technologies\, including 1) development of point-of-care PAI system for human inflammatory arthritis\, and 2) development of quantitative PAI for evaluating histological microfeatures and microenvironment of cancer. I will also present our recent development of a photoacoustic based anti-vascular technology named photo-mediated ultrasound therapy (PUT). Using a combination of a low intensity laser concurrently with ultrasound\, PUT can noninvasively remove microvessels without damaging surrounding biological tissue\, and shows potential to the treatment of a variety of diseases associated with neoangiogenesis\, such as age-related macular degeneration and diabetic retinopathy\, as well as port-wine stain and cancer. \nBiography\nDr. Xueding Wang is a Professor at the Department of Biomedical Engineering\, University of Michigan\, holding an adjunct Professor position at the Department of Radiology.  Before working as an independent principle investigator\, Dr. Wang received his Ph.D. from Dr. Lihong Wang’s lab at the Dwight Look College of Engineering at Texas A&M University\, and then finished postdoctoral training at the University of Michigan School of Medicine under the guidance of Prof. Paul Carson.  Dr. Wang has extensive experience in optical and ultrasound imaging and treatment system development and adaptation of novel diagnostic and therapeutic modalities to preclinical and clinical settings.  Sponsored by NIH\, NSF\, DoD and other funding agencies\, his research has led to over 110+ peer-reviewed publications.  At the University of Michigan Medical School\, a major part of his research is focused on clinical applications of photoacoustic imaging and therapy\, including those involving arthritis\, prostate cancer\, liver conditions\, breast cancer\, Crohn’s disease\, and eye conditions.  Dr. Wang is the recipient of the Sontag Foundation Fellow of the Arthritis National Research Foundation in 2005\, and the Distinguished Investigator Award of the Academy of Radiology Research in 2013. He is also sitting on the editorial boards of scientific journals including Photoacoustics\, Journal of Biomedical Optics\, Medical Physics\, and Ultrasonic Imaging\, and being the steering committee member of the Journal of Lightwave Technology. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Bernard Choi
URL:https://bli.uci.edu/event/xueding-wang-ph-d-2/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Wang-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190530T120000
DTEND;TZID=UTC:20190530T130000
DTSTAMP:20260420T031939
CREATED:20190521T224854Z
LAST-MODIFIED:20190524T003346Z
UID:21472-1559217600-1559221200@bli.uci.edu
SUMMARY:Kishan Dholakia\, PhD
DESCRIPTION:Professor at the University of St Andrews\, Scotland\nHonorary Adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India \nShaped Light for the Future of Biomedical Imaging\nAbstract\nI will review recent progress in various aspects of biomedical imaging at St Andrews in my group that has used innovation in shaping light in both space and time. I will cover the topics of wavelength modulated Raman analysis and digital holographic microscopy which we have used to develop label-free hemograms and studies for detection of phenotypically resistant mycobacterium tuberculosis. The main part of my talk will cover the topic of light sheet imaging with propagation invariant light beams (Airy\, Bessel) that offer excellent prospects for new studies in neuroscience\, developmental biology and histopathology. I will conclude with a novel form of imaging  where we use temporal focusing with single pixel detection for wide field multiphoton imaging at depth without the need to characterize the scattering media. The potential impact of these imaging modalities for disease detection and clinical implementation will be emphasized.  \nBiography\nKishan Dholakia is Professor at the University of St Andrews\, Scotland and an honorary adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India. He works on advanced imaging for neuroscience and cancer diagnosis\, beam shaping and optical manipulation leading a group of around 20 researchers. He has published over 300 journal papers\, has in excess of 26\,000 citations. His work is cited in the Guinness Book of Records 2015. He is a Fellow of the Royal Society of Edinburgh\, OSA and SPIE. In 2016 he won the R.W. Wood Prize of the Optical Society\, in 2017 he won the IOP Thomas Young Medal and Prize and in 2018 was the recipient of the SPIE Dennis Gabor Award. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/kishan-dholakia-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/dholakia.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190528T120000
DTEND;TZID=UTC:20190528T130000
DTSTAMP:20260420T031939
CREATED:20190521T222208Z
LAST-MODIFIED:20190521T223519Z
UID:21462-1559044800-1559048400@bli.uci.edu
SUMMARY:Elizabeth Hillman\, PhD
DESCRIPTION:Professor of Biomedical Engineering and Radiology\nZuckerman Mind Brain Behavior Institute at Columbia University \nUsing Light to Image at the Speed of Life\nAbstract\nLight is uniquely capable of probing and changing the electron and vibrational energy levels of molecules. As a result\, light can be used to spectrally discern a tissue’s chemical composition\, excite activity in a neuron and change the shape of the cornea in laser eye surgery. As lasers\, light-sources\, detectors and cameras continue to improve\, the opportunities to leverage the power of light for biomedical discovery\, diagnosis and treatment are continually expanding.\nAn area of enormous growth in the past decade has been the development of fluorescent protein-based reporters of cellular activity and optogenetics\, which combined have unlocked our ability to observe and manipulate cell signaling across scales. The result is a rich and expanding toolkit for studying how intact\, living organs\, organoids and organisms function\, and how they are affected by disease\, which in turn is fueling revolutions in neuroscience\, drug discovery\, personalized medicine. However\, a major bottleneck for these techniques is imaging speed. We developed swept confocally aligned planar excitation (SCAPE) microscopy to address this need for speed\, enabling 3D imaging in living tissues at over 100 volumes per second. SCAPE combines the high signal to noise and low photobleaching benefits of light sheet imaging with confocal descanning principles that enable high-speed scanning through a simple single\, stationary objective lens. Through diverse collaborations\, we have demonstrated SCAPE’s ability to image cellular activity in a wide range of living organisms including freely crawling Drosophila larvae\, the whole brain of behaving adult Drosophila\, zebrafish brain and heart\, 3D culture systems and the awake mouse cortex. We are now developing a range of new SCAPE systems including two-photon\, higher resolution and meso-scale versions\, as well as platforms for high-throughput and high-content imaging of cleared and expanded tissues\, and a miniaturized version of SCAPE for in-situ histopathology for clinical surgical guidance.\nSCAPE is one example of our innovations that have continually sought to leverage the power of light to capture in-vivo dynamics. In parallel we have developed image analysis methods for spatiotemporal and hyperspectral unmixing enabling us to relate complex multidimensional observations to physiological phenomena and behavior. We are applying these tools in our own studies of real-time brain-wide neural activity\, and to explore the relationship between blood flow and neural activity in the brain\, seeking biomarkers and therapeutic targets for neurovascular dysfunction.  \nBiography\nDr Elizabeth Hillman is a Professor of Biomedical Engineering and Radiology\, and a member of the Zuckerman Mind Brain Behavior Institute at Columbia University. Dr Hillman completed her undergraduate degree in Physics\, and PhD in Medical Physics and Bioengineering at University College London. After a year at a Boston medical device start-up company\, Dr Hillman completed postdoctoral training at the Martinos center for Biomedical Imaging at Massachusetts General Hospital / Harvard Medical School before becoming faculty at Columbia University in 2006. Prof Hillman has developed a range of novel approaches to in-vivo optical imaging and microscopy for both clinical and research applications. Her PhD work focused on time-resolved diffuse optical tomography of the breast and premature infant brain\, while her innovations since have included Dynamic Contrast enhanced molecular imaging (DyCE\, licensed to CRi Inc\, now PerkinElmer)\, Laminar Optical Tomography for brain and skin imaging\, hyperspectral two-photon microscopy\, wide-field optical mapping (WFOM) of neuronal activity and hemodynamics and most recently high-speed 3D swept confocally aligned planar excitation (SCAPE) microscopy (now licensed to Leica Microsystems). Continuing technology development includes new variants of SCAPE including a miniaturized clinical version for ‘real-time’ intrasurgical in-situ histopathology. Dr Hillman also has an active research program applying her in-vivo imaging tools to studying neurovascular coupling and brain-wide resting state neural activity dynamics in the healthy\, diseased and developing rodent brain. Dr Hillman has developed educational programs at Columbia University focusing on Disruptive Biomedical Design\, Biomedical Imaging and Advanced Microscopy. She is a Fellow of the OSA\, SPIE and AIMBE\, and her awards include an NSF CAREER Award in 2010\, the 2011 Optical Society of America Lomb Medal for contributions to optics at a young age\, and the SPIE Biophotonics Technology Innovator award in 2018.  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/elizabeth-hillman-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/hillman_UCI.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190516T120000
DTEND;TZID=UTC:20190516T130000
DTSTAMP:20260420T031939
CREATED:20190201T024715Z
LAST-MODIFIED:20190516T224250Z
UID:7506-1558008000-1558011600@bli.uci.edu
SUMMARY:Alon Gorodetsky\, PhD
DESCRIPTION:UC Irvine Assoc. Professor\nDepartment of Chemical Engineering and Material Sciences \nDynamic Materials Inspired By Cephalopods\nAbstract\nCephalopods (squid\, octopuses\, and cuttlefish) have captivated the imagination of both the general public and scientists alike for more than a century due to their visually stunning camouflage displays\, sophisticated nervous systems\, and complex behavioral patterns. Given their unique capabilities and characteristics\, it is not surprising that these marine invertebrates have emerged as exciting models for novel materials and systems. Within this context\, our laboratory has developed various cephalopod-derived and cephalopod-inspired materials with unique functionalities.  Our findings hold implications for next-generation adaptive camouflage devices\, sensitive bioelectronic platforms\, and advanced renewable energy technologies. \nBiography\nDr. Alon Gorodetsky is an Associate Professor in the Department of Chemical and Biomolecular Engineering at the University of California\, Irvine\, with joint appointments in the Department of Chemistry and the Department of Materials Science and Engineering. Dr. Gorodetsky obtained B.S. degrees in Engineering Physics and Materials Science at Cornell University and a Ph.D. in Chemistry at the California Institute of Technology. He subsequently completed postdoctoral work as a National Science Foundation American Competitiveness in Chemistry Fellow at Columbia University. His current research is focused on the development of macromolecular and biomolecular materials inspired by natural systems\, with an emphasis on cephalopods. His work has been featured in Popular Science\, Popular Mechanics\, Newsweek\, The Telegraph\, Wired\, The Verge\, Fox News\, NPR Marketplace\, BBC World\, CNN and other popular media. For his studies\, Dr. Gorodetsky has received several awards\, including the Henry Samueli School of Engineering Mid-Career Faculty Excellence in Research Award\, Applied Innovation Early Career Innovator of the Year Award\, the AFOSR Young Investigator Award\, the DARPA Young Faculty Award with the Director’s Option\, and the Presidential Early Career Award for Scientists and Engineers. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/alon-gorodetsky-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2019/01/alon-gorodetsky.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190513T121500
DTEND;TZID=UTC:20190513T131500
DTSTAMP:20260420T031939
CREATED:20190503T001639Z
LAST-MODIFIED:20190503T010125Z
UID:21411-1557749700-1557753300@bli.uci.edu
SUMMARY:Brian W. Pogue\, Ph.D.
DESCRIPTION:MacLean Professor of Engineering\, Dartmouth\nEditor-in-Chief\, Journal of Biomedical Optics\, SPIE Press \nImaging Medicine\nAbstract\nWhile the field of Medical Imaging is dominated by radiological devices\, the field of Imaging Medicine today is dominated by optical devices.   Optical imaging is commonly used at the point-of-care\, where patient and physician are in the same room together.  These procedure-based tools are used to capture unique contrast features that help guide medical decisions. In the Optics in Medicine cluster at Dartmouth scientific discovery and technology development are advanced side-by-side in areas such as image-guided spectroscopy of cancer\, surgical guidance tools with molecular specificity\, smart photodynamic therapy\, and novel radiologic guidance and dosimetry tools for remote non-contact monitoring of Cherenkov and scintillation light.  Examples from each will be used to highlight innovations in translational research that have gone from scientific concept through to technology development and into clinical trials.  Translating optical Imaging systems beyond the pilot trial phase involves the type of R&D which only companies can accomplish\, and so examples of strategic partnerships with companies in translational research will be shown.  Venture creation through a startup company\, DoseOptics LLC\, will be highlighted in which this pathway has enabled testing and deployment of a fundamentally new technology to image radiation dose delivery in real time for the first time in history\, and extended to multiple cancer centers. The invention and translation of new optical tools to Image Medicine is an enormous economic force today\, and the growth in science and technology opportunities and NIH funding within this field is discussed. \nBiography\nBrian W. Pogue\, Ph.D. is the MacLean Professor of Engineering at Dartmouth in Hanover\, New Hampshire USA\, and is Adjunct Professor in Surgery at the Geisel School of Medicine and Adjunct Professor of Life Science & Technology at Xi’an Jiaotong University\, China.  His Doctoral work in Physics from McMaster University\, Canada\, was followed by a Research Fellow position at the Wellman Center for Photomedicine at Harvard Medical School.  At Dartmouth since 1996\, he works in the area of Optics in Medicine\, with a focus on novel imaging systems for characterizing cancer and tracking therapy. Following being Dean of Graduate Studies at Dartmouth from 2008-2012\, he is now Director of MS and PhD Programs in Engineering Science & Medical Physics and coordinates the Center for Imaging Medicine.  He has published over 350 peer-reviewed papers and 400 conference papers in cancer therapy\, surgery\, medicine\, medical oncology\, and radiotherapy.  His research is funded by the NIH through two Program Project grants as well as several individual R01 grants. He is the Editor-in-Chief of the Journal of Biomedical Optics published by SPIE and is a Fellow of the International Society for Optics and Photonics (SPIE)\, the Optical Society of America (OSA) and the American Institute of Medical and Biological Engineers (AIMBE).  He recently founded the startup company DoseOptics LLC\, making the world’s first camera to image radiotherapy dose delivery. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/brian-pogue-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/BrianPogue.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190425T120000
DTEND;TZID=UTC:20190425T130000
DTSTAMP:20260420T031939
CREATED:20190125T041910Z
LAST-MODIFIED:20190404T234907Z
UID:7355-1556193600-1556197200@bli.uci.edu
SUMMARY:Xiaolin Nan\, PhD
DESCRIPTION:Department of Biomedical Engineering\nOregon Health & Sciences University\nPortland\, Oregon \nVisualizing Tumor Biology: From Single Molecules to Systems\nCancer is a systems disease that arises from complex molecular abnormalities\, whereby effective treatment requires insight into tumorigenesis at multiple levels – from individual molecules to whole cells and tumors. Research in our laboratory aims to build multiscale\, systems-level models of tumorigenic signaling by leveraging recent developments in single-molecule\, superresolution\, and correlative light – electron microscopies. Using the human epidermal growth factor receptors (e.g. HER2) and the Ras small GTPases as model systems\, we will showcase how quantitative imaging at the single-molecule and nanometer scales reveals previously unknown aspects of these common oncogenic drivers. These findings underscore the importance of studying tumor biology within the intact spatial and biological context\, which current omics-based systems-biology approaches have largely overlooked. We will also discuss ongoing efforts toward constructing spatially-integrated models of tumorigenic signaling networks through multiplexed and high-throughput superresolution imaging\, as well as the implications of our findings in targeted cancer therapies. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Eric Potma
URL:https://bli.uci.edu/event/xiaolin-nan-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/01/nan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190404T120000
DTEND;TZID=UTC:20190404T130000
DTSTAMP:20260420T031939
CREATED:20190125T025111Z
LAST-MODIFIED:20190227T084914Z
UID:7423-1554379200-1554382800@bli.uci.edu
SUMMARY:Vincent Daria\, PhD
DESCRIPTION:Applied Physics\nFellow\, Group Leader (Neuro-photonics Group)\nANU College of Health and Medicine\nAustralian National University Canberra\, AU \n  \nUsing Complex Light Patterns To Understand Brain Circuits\nWe aim to understand how information is processed in cortical circuits of the mammalian brain.  To achieve this\, we use complex light patterns to stimulate and record the activity of single cortical neurons in a rat brain slice.  We use holographic projection of an ultrafast laser to produce multiple foci\, where each focus emulates a synaptic input or an optical recording probe. To emulate synaptic inputs\, multiple foci are directed onto spines of a neuron and gated illumination enables localized two-photon (2P) photolysis of caged neurotransmitters. Patterned spatio-temporal release of neurotransmitters onto multiple spines allows us to study the input-output characteristics of single neurons in the cortex. As an optical recording probe\, each focus excites neuronal activity reporters via 2P multi-foci excitation.  The fluorescence emanating from all foci are simultaneously recorded using an electron-multiplying charge-coupled device (EMCCD) camera thereby enabling simultaneous multi-channel recording of the neuronal activity from multiple sites.  We report recording of neuronal activity from two types of reporters: (1) calcium indicator\, Cal520; and (2) voltage indicator\, JPW1114.  We optically recorded the activity evoked by the neuron following injection of current onto the soma. Using this technique\, we have uniquely identified a crucial function of a specific set of dendrites for learning and memory. Moreover\, we can disable such function by prunning the specific dendrite via highly targetted femtosecond laser dendrotomy. Using complex light patterns to understand the input-output transfer function of single neurons enables bottom-up approach to understand information processing in the brain. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Daryl C Preece
URL:https://bli.uci.edu/event/vincent-daria-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/01/daria.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190327
DTEND;VALUE=DATE:20190401
DTSTAMP:20260420T031939
CREATED:20190127T000808Z
LAST-MODIFIED:20190201T024816Z
UID:7449-1553644800-1554076799@bli.uci.edu
SUMMARY:ASLMS 2019
DESCRIPTION:Hear why you can’t miss ASLMS 2019. \nDenver\, Colorado March 27 -31\, 2019. Visit http://www.aslms.org/annual-conference-2019 to register.
URL:https://bli.uci.edu/event/aslms-2019/
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2019/01/FPEFtfga_400x400.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190315T140000
DTEND;TZID=UTC:20190315T150000
DTSTAMP:20260420T031939
CREATED:20190221T063747Z
LAST-MODIFIED:20190221T064525Z
UID:20982-1552658400-1552662000@bli.uci.edu
SUMMARY:Xueding Wang\, Ph.D.
DESCRIPTION:Department of Biomedical Engineering\nDepartment of Radiology\nUniversity of Michigan School of Medicine \n  \nLight plus Sound: Imaging and Treatment\nPhotoacoustic imaging (PAI)\, also referred to as optoacoustic imaging\, is an emerging biomedical imaging technology that is noninvasive\, nonionizing\, with high sensitivity\, satisfactory imaging depth and good temporal and spatial resolution. Like conventional optical imaging\, PAI presents the optical contrast which is highly sensitive to molecular conformation and biochemical contents of tissues and can aid in describing tissue metabolic and hemodynamic changes. Unlike conventional optical imaging\, the spatial resolution of PAI is not limited by the strong light diffusion but instead determined by the measurement of light-generated ultrasonic signals. As a result\, the resolution of PAI is parallel to high-frequency ultrasonography. \nAt the University of Michigan School of Medicine\, our research has been focused on clinical applications of PAI\, including arthritis\, cancer\, liver conditions\, Crohn’s disease\, and eye diseases.  In this talk\, I will introduce some of our recently development of PAI technologies\, including 1) development of point-of-care PAI system for human inflammatory arthritis\, and 2) development of quantitative PAI for evaluating histological microfeatures and microenvironment of cancer. I will also present our recent development of a photoacoustic based anti-vascular technology named photo-mediated ultrasound therapy (PUT). Using a combination of a low intensity laser concurrently with ultrasound\, PUT can noninvasively remove microvessels without damaging surrounding biological tissue\, and shows potential to the treatment of a variety of diseases associated with neoangiogenesis\, such as age-related macular degeneration and diabetic retinopathy. \n  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. \nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/xueding-wang-ph-d/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Wang-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190220T123000
DTEND;TZID=UTC:20190220T133000
DTSTAMP:20260420T031939
CREATED:20190214T091649Z
LAST-MODIFIED:20190215T020121Z
UID:12372-1550665800-1550669400@bli.uci.edu
SUMMARY:Logan Swartz\, PhD
DESCRIPTION:Liu Group\, UC Davis \nScanning Probe Microscopy Based 3D Nanolithography\nThree dimensional (3D) printing has been an active area of research and development due to its capability to produce 3D objects by design.  Miniaturization and improvement of spatial resolution are major challenges in current 3D printing technology development.  This presentation reports advances in bringing 3D nanolithography to the nanometer scale using scanning probe microscopy (SPM).  SPM uses nanometer scale sharp tips to probe localized tip material interactions at the atomic and/or molecular level.  Taking advantage of the interactions to instead print materials\, in conjunction with SPM’s nanometer precision piezo based positioning systems and local surface chemistry\, we have been able to develop methods to advance 3D printing to 3D nanolithography/nanoprinting. \nThree methods were developed.  The first presented culminated in the first patented\, 3D nanoprinter.  It involves directly delivering polyelectrolyte complex materials layer-by-layer using an atomic force microscopy (AFM) probe.  This enabled creation of 3D nanostructures with nanometer precision in all three dimensions.  The second method describes development of a new technique for near-field scanning optical microscopy (NSOM) nanolithography.  NSOM lithography uses an SPM probe as a local light source to break the diffraction limit to perform photolithography.  We have created new versions of these probes by developing ways to attach fluorescent nanoparticles to the end of AFM probes.  The third method is a convenient way to modify with in situ control AFM probes to have a flat surface/plateau at their end.  These plateau probes\, mounted on an AFM\, are useful for compression studies to measure the created nanostructures’ nanomechanical properties. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Michael Berns
URL:https://bli.uci.edu/event/logan-swartz-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Logan-Swartz.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190219T100000
DTEND;TZID=UTC:20190219T110000
DTSTAMP:20260420T031939
CREATED:20190219T104205Z
LAST-MODIFIED:20190220T005029Z
UID:20146-1550570400-1550574000@bli.uci.edu
SUMMARY:Junle Qu\, Ph.D
DESCRIPTION:Professor of Optical Engineering\nShenzhen University \nSuper-resolution for live cell imaging\nSuper-resolution imaging has made remarkable progress in recent years\, providing a powerful tool for biology. It allows for the observation of fine structures of cells\, cellular dynamics and cellular functions at nanometer scale or even single molecular level\, which greatly promotes the development of life science and many other fields. In this talk I will present our recent work in super-resolution optical microscopy. By combining stimulation emission depletion (STED) microscopy and fluorescence lifetime imaging (FLIM)\, we can improve the spatial resolution of STED and perform FLIM imaging at nanometer resolution. Novel fluorescent probes with low STED laser power and experiment strategies were designed for live cell mitochondria imaging. Coherent adaptive optical technique (COAT) has been implemented in STED microscope to circumvent the scattering and aberration effect for thick sample imaging. Stochastic optical reconstruction microscopy (STORM) superresolution imaging of mitochondrial membrane in live cells was achieved by the development of new fluorescent probes\, improved imaging system and optimized single molecule localization algorithm. These developments make it possible to study dynamic events and complex functions in living cells\, even with a single conventional microscope. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/junle-qu/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Junle-Qu.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190208T120000
DTEND;TZID=UTC:20190208T130000
DTSTAMP:20260420T031939
CREATED:20190202T034746Z
LAST-MODIFIED:20190202T042038Z
UID:7530-1549627200-1549630800@bli.uci.edu
SUMMARY:Inga Saknite\, PhD
DESCRIPTION:Vanderbilt Translational Skin Imaging Clinic\nVanderbilt University Medical Center \nLeukocyte dynamics in human skin capillaries by noninvasive reflectance confocal microscopy\nInflammatory tissue response is one of the first and most common manifestations of acute graft-versus-host disease (aGVHD)\, a potentially deadly immune-mediated disease that occurs in 30-60% of patients after hematopoietic stem cell transplantation. A fundamental challenge in developing effective treatment strategies for aGVHD is the lack of tools to study disease biology in real-time in post-transplant patients. The inflammatory tissue response causes increased expression of specialized endothelial proteins on vessel walls making leukocytes to roll\, adhere and eventually extravasate into the tissue at a higher rate than in normal conditions. Although the importance of leukocyte-endothelial interactions to detect and track inflammation has been well shown in murine models\, there are no published clinical studies in humans. In this study\, we explore the feasibility to detect presence of aGVHD in post-transplant patients through the imaging of in vivo leukocyte motion. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Mihaela Balu
URL:https://bli.uci.edu/event/inga-saknite/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/inga.jpg
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