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X-WR-CALDESC:Events for Beckman Laser Institute
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190220T123000
DTEND;TZID=UTC:20190220T133000
DTSTAMP:20260910T214247
CREATED:20190214T091649Z
LAST-MODIFIED:20190215T020121Z
UID:12372-1550665800-1550669400@bli.uci.edu
SUMMARY:Logan Swartz\, PhD
DESCRIPTION:Liu Group\, UC Davis \nScanning Probe Microscopy Based 3D Nanolithography\nThree dimensional (3D) printing has been an active area of research and development due to its capability to produce 3D objects by design.  Miniaturization and improvement of spatial resolution are major challenges in current 3D printing technology development.  This presentation reports advances in bringing 3D nanolithography to the nanometer scale using scanning probe microscopy (SPM).  SPM uses nanometer scale sharp tips to probe localized tip material interactions at the atomic and/or molecular level.  Taking advantage of the interactions to instead print materials\, in conjunction with SPM’s nanometer precision piezo based positioning systems and local surface chemistry\, we have been able to develop methods to advance 3D printing to 3D nanolithography/nanoprinting. \nThree methods were developed.  The first presented culminated in the first patented\, 3D nanoprinter.  It involves directly delivering polyelectrolyte complex materials layer-by-layer using an atomic force microscopy (AFM) probe.  This enabled creation of 3D nanostructures with nanometer precision in all three dimensions.  The second method describes development of a new technique for near-field scanning optical microscopy (NSOM) nanolithography.  NSOM lithography uses an SPM probe as a local light source to break the diffraction limit to perform photolithography.  We have created new versions of these probes by developing ways to attach fluorescent nanoparticles to the end of AFM probes.  The third method is a convenient way to modify with in situ control AFM probes to have a flat surface/plateau at their end.  These plateau probes\, mounted on an AFM\, are useful for compression studies to measure the created nanostructures’ nanomechanical properties. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Michael Berns
URL:https://bli.uci.edu/event/logan-swartz-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Logan-Swartz.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190219T100000
DTEND;TZID=UTC:20190219T110000
DTSTAMP:20260910T214247
CREATED:20190219T104205Z
LAST-MODIFIED:20190220T005029Z
UID:20146-1550570400-1550574000@bli.uci.edu
SUMMARY:Junle Qu\, Ph.D
DESCRIPTION:Professor of Optical Engineering\nShenzhen University \nSuper-resolution for live cell imaging\nSuper-resolution imaging has made remarkable progress in recent years\, providing a powerful tool for biology. It allows for the observation of fine structures of cells\, cellular dynamics and cellular functions at nanometer scale or even single molecular level\, which greatly promotes the development of life science and many other fields. In this talk I will present our recent work in super-resolution optical microscopy. By combining stimulation emission depletion (STED) microscopy and fluorescence lifetime imaging (FLIM)\, we can improve the spatial resolution of STED and perform FLIM imaging at nanometer resolution. Novel fluorescent probes with low STED laser power and experiment strategies were designed for live cell mitochondria imaging. Coherent adaptive optical technique (COAT) has been implemented in STED microscope to circumvent the scattering and aberration effect for thick sample imaging. Stochastic optical reconstruction microscopy (STORM) superresolution imaging of mitochondrial membrane in live cells was achieved by the development of new fluorescent probes\, improved imaging system and optimized single molecule localization algorithm. These developments make it possible to study dynamic events and complex functions in living cells\, even with a single conventional microscope. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/junle-qu/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/Junle-Qu.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190208T120000
DTEND;TZID=UTC:20190208T130000
DTSTAMP:20260910T214247
CREATED:20190202T034746Z
LAST-MODIFIED:20190202T042038Z
UID:7530-1549627200-1549630800@bli.uci.edu
SUMMARY:Inga Saknite\, PhD
DESCRIPTION:Vanderbilt Translational Skin Imaging Clinic\nVanderbilt University Medical Center \nLeukocyte dynamics in human skin capillaries by noninvasive reflectance confocal microscopy\nInflammatory tissue response is one of the first and most common manifestations of acute graft-versus-host disease (aGVHD)\, a potentially deadly immune-mediated disease that occurs in 30-60% of patients after hematopoietic stem cell transplantation. A fundamental challenge in developing effective treatment strategies for aGVHD is the lack of tools to study disease biology in real-time in post-transplant patients. The inflammatory tissue response causes increased expression of specialized endothelial proteins on vessel walls making leukocytes to roll\, adhere and eventually extravasate into the tissue at a higher rate than in normal conditions. Although the importance of leukocyte-endothelial interactions to detect and track inflammation has been well shown in murine models\, there are no published clinical studies in humans. In this study\, we explore the feasibility to detect presence of aGVHD in post-transplant patients through the imaging of in vivo leukocyte motion. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Mihaela Balu
URL:https://bli.uci.edu/event/inga-saknite/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/02/inga.jpg
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