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BEGIN:VEVENT
DTSTART;TZID=UTC:20190513T121500
DTEND;TZID=UTC:20190513T131500
DTSTAMP:20190503T010125Z
CREATED:20190503T001639Z
LAST-MODIFIED:20190503T010125Z
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SUMMARY:Brian W. Pogue\, Ph.D.
DESCRIPTION:MacLean Professor of Engineering\, Dartmouth\nEditor-in-Chief\, Journal of Biomedical Optics\, SPIE Press \nImaging Medicine\nAbstract\nWhile the field of Medical Imaging is dominated by radiological devices\, the field of Imaging Medicine today is dominated by optical devices.   Optical imaging is commonly used at the point-of-care\, where patient and physician are in the same room together.  These procedure-based tools are used to capture unique contrast features that help guide medical decisions. In the Optics in Medicine cluster at Dartmouth scientific discovery and technology development are advanced side-by-side in areas such as image-guided spectroscopy of cancer\, surgical guidance tools with molecular specificity\, smart photodynamic therapy\, and novel radiologic guidance and dosimetry tools for remote non-contact monitoring of Cherenkov and scintillation light.  Examples from each will be used to highlight innovations in translational research that have gone from scientific concept through to technology development and into clinical trials.  Translating optical Imaging systems beyond the pilot trial phase involves the type of R&D which only companies can accomplish\, and so examples of strategic partnerships with companies in translational research will be shown.  Venture creation through a startup company\, DoseOptics LLC\, will be highlighted in which this pathway has enabled testing and deployment of a fundamentally new technology to image radiation dose delivery in real time for the first time in history\, and extended to multiple cancer centers. The invention and translation of new optical tools to Image Medicine is an enormous economic force today\, and the growth in science and technology opportunities and NIH funding within this field is discussed. \nBiography\nBrian W. Pogue\, Ph.D. is the MacLean Professor of Engineering at Dartmouth in Hanover\, New Hampshire USA\, and is Adjunct Professor in Surgery at the Geisel School of Medicine and Adjunct Professor of Life Science & Technology at Xi’an Jiaotong University\, China.  His Doctoral work in Physics from McMaster University\, Canada\, was followed by a Research Fellow position at the Wellman Center for Photomedicine at Harvard Medical School.  At Dartmouth since 1996\, he works in the area of Optics in Medicine\, with a focus on novel imaging systems for characterizing cancer and tracking therapy. Following being Dean of Graduate Studies at Dartmouth from 2008-2012\, he is now Director of MS and PhD Programs in Engineering Science & Medical Physics and coordinates the Center for Imaging Medicine.  He has published over 350 peer-reviewed papers and 400 conference papers in cancer therapy\, surgery\, medicine\, medical oncology\, and radiotherapy.  His research is funded by the NIH through two Program Project grants as well as several individual R01 grants. He is the Editor-in-Chief of the Journal of Biomedical Optics published by SPIE and is a Fellow of the International Society for Optics and Photonics (SPIE)\, the Optical Society of America (OSA) and the American Institute of Medical and Biological Engineers (AIMBE).  He recently founded the startup company DoseOptics LLC\, making the world’s first camera to image radiotherapy dose delivery. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/brian-pogue-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/BrianPogue.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190516T120000
DTEND;TZID=UTC:20190516T130000
DTSTAMP:20190516T224250Z
CREATED:20190201T024715Z
LAST-MODIFIED:20190516T224250Z
UID:7506-1558008000-1558011600@bli.uci.edu
SUMMARY:Alon Gorodetsky\, PhD
DESCRIPTION:UC Irvine Assoc. Professor\nDepartment of Chemical Engineering and Material Sciences \nDynamic Materials Inspired By Cephalopods\nAbstract\nCephalopods (squid\, octopuses\, and cuttlefish) have captivated the imagination of both the general public and scientists alike for more than a century due to their visually stunning camouflage displays\, sophisticated nervous systems\, and complex behavioral patterns. Given their unique capabilities and characteristics\, it is not surprising that these marine invertebrates have emerged as exciting models for novel materials and systems. Within this context\, our laboratory has developed various cephalopod-derived and cephalopod-inspired materials with unique functionalities.  Our findings hold implications for next-generation adaptive camouflage devices\, sensitive bioelectronic platforms\, and advanced renewable energy technologies. \nBiography\nDr. Alon Gorodetsky is an Associate Professor in the Department of Chemical and Biomolecular Engineering at the University of California\, Irvine\, with joint appointments in the Department of Chemistry and the Department of Materials Science and Engineering. Dr. Gorodetsky obtained B.S. degrees in Engineering Physics and Materials Science at Cornell University and a Ph.D. in Chemistry at the California Institute of Technology. He subsequently completed postdoctoral work as a National Science Foundation American Competitiveness in Chemistry Fellow at Columbia University. His current research is focused on the development of macromolecular and biomolecular materials inspired by natural systems\, with an emphasis on cephalopods. His work has been featured in Popular Science\, Popular Mechanics\, Newsweek\, The Telegraph\, Wired\, The Verge\, Fox News\, NPR Marketplace\, BBC World\, CNN and other popular media. For his studies\, Dr. Gorodetsky has received several awards\, including the Henry Samueli School of Engineering Mid-Career Faculty Excellence in Research Award\, Applied Innovation Early Career Innovator of the Year Award\, the AFOSR Young Investigator Award\, the DARPA Young Faculty Award with the Director’s Option\, and the Presidential Early Career Award for Scientists and Engineers. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/alon-gorodetsky-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/png:https://bli.uci.edu/wp-content/uploads/2019/01/alon-gorodetsky.png
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190528T120000
DTEND;TZID=UTC:20190528T130000
DTSTAMP:20190521T223519Z
CREATED:20190521T222208Z
LAST-MODIFIED:20190521T223519Z
UID:21462-1559044800-1559048400@bli.uci.edu
SUMMARY:Elizabeth Hillman\, PhD
DESCRIPTION:Professor of Biomedical Engineering and Radiology\nZuckerman Mind Brain Behavior Institute at Columbia University \nUsing Light to Image at the Speed of Life\nAbstract\nLight is uniquely capable of probing and changing the electron and vibrational energy levels of molecules. As a result\, light can be used to spectrally discern a tissue’s chemical composition\, excite activity in a neuron and change the shape of the cornea in laser eye surgery. As lasers\, light-sources\, detectors and cameras continue to improve\, the opportunities to leverage the power of light for biomedical discovery\, diagnosis and treatment are continually expanding.\nAn area of enormous growth in the past decade has been the development of fluorescent protein-based reporters of cellular activity and optogenetics\, which combined have unlocked our ability to observe and manipulate cell signaling across scales. The result is a rich and expanding toolkit for studying how intact\, living organs\, organoids and organisms function\, and how they are affected by disease\, which in turn is fueling revolutions in neuroscience\, drug discovery\, personalized medicine. However\, a major bottleneck for these techniques is imaging speed. We developed swept confocally aligned planar excitation (SCAPE) microscopy to address this need for speed\, enabling 3D imaging in living tissues at over 100 volumes per second. SCAPE combines the high signal to noise and low photobleaching benefits of light sheet imaging with confocal descanning principles that enable high-speed scanning through a simple single\, stationary objective lens. Through diverse collaborations\, we have demonstrated SCAPE’s ability to image cellular activity in a wide range of living organisms including freely crawling Drosophila larvae\, the whole brain of behaving adult Drosophila\, zebrafish brain and heart\, 3D culture systems and the awake mouse cortex. We are now developing a range of new SCAPE systems including two-photon\, higher resolution and meso-scale versions\, as well as platforms for high-throughput and high-content imaging of cleared and expanded tissues\, and a miniaturized version of SCAPE for in-situ histopathology for clinical surgical guidance.\nSCAPE is one example of our innovations that have continually sought to leverage the power of light to capture in-vivo dynamics. In parallel we have developed image analysis methods for spatiotemporal and hyperspectral unmixing enabling us to relate complex multidimensional observations to physiological phenomena and behavior. We are applying these tools in our own studies of real-time brain-wide neural activity\, and to explore the relationship between blood flow and neural activity in the brain\, seeking biomarkers and therapeutic targets for neurovascular dysfunction.  \nBiography\nDr Elizabeth Hillman is a Professor of Biomedical Engineering and Radiology\, and a member of the Zuckerman Mind Brain Behavior Institute at Columbia University. Dr Hillman completed her undergraduate degree in Physics\, and PhD in Medical Physics and Bioengineering at University College London. After a year at a Boston medical device start-up company\, Dr Hillman completed postdoctoral training at the Martinos center for Biomedical Imaging at Massachusetts General Hospital / Harvard Medical School before becoming faculty at Columbia University in 2006. Prof Hillman has developed a range of novel approaches to in-vivo optical imaging and microscopy for both clinical and research applications. Her PhD work focused on time-resolved diffuse optical tomography of the breast and premature infant brain\, while her innovations since have included Dynamic Contrast enhanced molecular imaging (DyCE\, licensed to CRi Inc\, now PerkinElmer)\, Laminar Optical Tomography for brain and skin imaging\, hyperspectral two-photon microscopy\, wide-field optical mapping (WFOM) of neuronal activity and hemodynamics and most recently high-speed 3D swept confocally aligned planar excitation (SCAPE) microscopy (now licensed to Leica Microsystems). Continuing technology development includes new variants of SCAPE including a miniaturized clinical version for ‘real-time’ intrasurgical in-situ histopathology. Dr Hillman also has an active research program applying her in-vivo imaging tools to studying neurovascular coupling and brain-wide resting state neural activity dynamics in the healthy\, diseased and developing rodent brain. Dr Hillman has developed educational programs at Columbia University focusing on Disruptive Biomedical Design\, Biomedical Imaging and Advanced Microscopy. She is a Fellow of the OSA\, SPIE and AIMBE\, and her awards include an NSF CAREER Award in 2010\, the 2011 Optical Society of America Lomb Medal for contributions to optics at a young age\, and the SPIE Biophotonics Technology Innovator award in 2018.  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/elizabeth-hillman-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/hillman_UCI.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190530T120000
DTEND;TZID=UTC:20190530T130000
DTSTAMP:20190524T003346Z
CREATED:20190521T224854Z
LAST-MODIFIED:20190524T003346Z
UID:21472-1559217600-1559221200@bli.uci.edu
SUMMARY:Kishan Dholakia\, PhD
DESCRIPTION:Professor at the University of St Andrews\, Scotland\nHonorary Adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India \nShaped Light for the Future of Biomedical Imaging\nAbstract\nI will review recent progress in various aspects of biomedical imaging at St Andrews in my group that has used innovation in shaping light in both space and time. I will cover the topics of wavelength modulated Raman analysis and digital holographic microscopy which we have used to develop label-free hemograms and studies for detection of phenotypically resistant mycobacterium tuberculosis. The main part of my talk will cover the topic of light sheet imaging with propagation invariant light beams (Airy\, Bessel) that offer excellent prospects for new studies in neuroscience\, developmental biology and histopathology. I will conclude with a novel form of imaging  where we use temporal focusing with single pixel detection for wide field multiphoton imaging at depth without the need to characterize the scattering media. The potential impact of these imaging modalities for disease detection and clinical implementation will be emphasized.  \nBiography\nKishan Dholakia is Professor at the University of St Andrews\, Scotland and an honorary adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India. He works on advanced imaging for neuroscience and cancer diagnosis\, beam shaping and optical manipulation leading a group of around 20 researchers. He has published over 300 journal papers\, has in excess of 26\,000 citations. His work is cited in the Guinness Book of Records 2015. He is a Fellow of the Royal Society of Edinburgh\, OSA and SPIE. In 2016 he won the R.W. Wood Prize of the Optical Society\, in 2017 he won the IOP Thomas Young Medal and Prize and in 2018 was the recipient of the SPIE Dennis Gabor Award. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://bli.uci.edu/event/kishan-dholakia-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/05/dholakia.jpg
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