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X-WR-CALNAME:Beckman Laser Institute
X-ORIGINAL-URL:https://bli.uci.edu
X-WR-CALDESC:Events for Beckman Laser Institute
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TZID:UTC
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TZOFFSETFROM:+0000
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DTSTART:20180101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190701T120000
DTEND;TZID=UTC:20190701T130000
DTSTAMP:20190613T052528Z
CREATED:20190613T052528Z
LAST-MODIFIED:20190613T052528Z
UID:21577-1561982400-1561986000@bli.uci.edu
SUMMARY:Nicholas J. Durr\, Ph.D.
DESCRIPTION:Assistant Professor of Biomedical Engineering\, Johns Hopkins University \nDesigning Solutions to Healthcare Needs With Computational Biophotonics\nAbstract\nComputational biophotonics pairs optical system design with the development of intelligent algorithms to extract meaningful data from interrogated tissues (often via an unintuitive computational image). With the recent dramatic advances in deep learning tools\, there are many exciting opportunities to apply data-driven models with novel imaging systems to create impactful medical devices. I will present our efforts in developing and translating computational biophotonics medical devices for a variety of important healthcare needs\, including: (1) improving the management of colorectal cancer with deep learning and the computational colonoscope\, (2) enabling a non-invasive blood count with gradient-field capillaroscopy\, and (3) making eye care more accessible with a low-cost\, handheld wavefront aberrometer. \nBiography\nNicholas Durr is an Assistant Professor of Biomedical Engineering at Johns Hopkins University and the co-Director of Undergraduate Programs at the Center for Bioengineering Innovation and Design (CBID). He received a B.S. in Electrical Engineering and Computer Science from U.C. Berkeley in 2003\, worked as a Research Engineer at Nellcor from 2003 to 2004\, and received a Ph.D. in Biomedical Engineering from U.T. Austin in 2010. He completed a Postdoctoral Fellowship at Harvard Medical School in 2011 and was an independent investigator at MIT from 2011 to 2014 as a Fellow in the M+Visión Consortium. In 2013 he co-founded PlenOptika\, which he led as CEO until he joined Hopkins in 2016.  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/nicholas-durr-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/NDURR.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190702T120000
DTEND;TZID=UTC:20190702T130000
DTSTAMP:20190613T053318Z
CREATED:20190613T053318Z
LAST-MODIFIED:20190613T053318Z
UID:21581-1562068800-1562072400@bli.uci.edu
SUMMARY:Stefan Carp\, PhD
DESCRIPTION:Assistant Professor of Radiology at Harvard Medical School \nNon-invasive Biophotonics for Personalized Medicine\nAbstract\nPersonalized or precision medicine is an emerging paradigm in health care delivery that seeks to tailor medical treatment to the individual characteristics\, needs and preferences of each patient. Biophotonic technologies are likely to play a significant role in realizing the benefits of personalized medicine by leveraging novel contrast mechanisms to offer timely feedback on treatment progress\, and can be integrated into compact\, cost-effective devices that are suitable for longitudinal patient monitoring.\nOur work has been focused on the technology development and clinical translation of optical imaging and sensing using near-infrared light. This talk will report on our efforts in two major application areas:  in the context of breast cancer management\, we are combining dynamic diffuse optical tomography with x-ray digital breast tomosynthesis to improve breast cancer diagnosis and neoadjuvant chemotherapy monitoring outcomes; in the context of neuromonitoring\, we are advancing methods for the accurate quantification of brain health in the presence of systemic physiology interference in adults\, by using a combination of near-infrared spectroscopy and diffuse correlation spectroscopy techniques together with advanced light transport models\, with the goal to offer new tools for improving the management of brain perfusion in patients undergoing cardiovascular interventions. \nBiography\nDr. Stefan Carp is an Assistant Professor of Radiology at Harvard Medical School and a member of Massachusetts General Hospital Martinos Center Optics Division. He received his BS degrees in chemistry and chemical engineering from MIT and pursued his doctorate at U.C. Irvine (UCI) under the supervision of Dr. Vasan Venugopalan. At UCI he discovered the field of biomedical optics and developed a non-contact optoacoustic imaging system for his dissertation project. After graduation\, he worked on optical breast imaging after moving to the Massachusetts General Hospital\, where he now leads a research group that focuses on the development of novel techniques for tissue hemodynamics and oxygen metabolism monitoring to help advance personalized medicine. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/stefan-carp-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/CARP.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190708T120000
DTEND;TZID=UTC:20190708T130000
DTSTAMP:20190618T060334Z
CREATED:20190618T055844Z
LAST-MODIFIED:20190618T060334Z
UID:21585-1562587200-1562590800@bli.uci.edu
SUMMARY:Mihaela Balu\, Ph.D.
DESCRIPTION:Associate Researcher at the Beckman Laser Institute\, UC Irvine \nClinical skin imaging with multiphoton microscopy– current strategies and future directions \nAbstract\nThe ability of multiphoton microscopy (MPM) to generate high-resolution 3D maps of specific tissue molecular compounds led to its widespread use in biomedical applications. MPM has been successfully employed in research labs for basic biology studies and imaging of small animal models but due to the complexity and cost of the microscope systems\, only recently it started to be explored as a technique for non-invasive in-vivo human skin imaging. In the US\, the first clinical skin imaging research studies using MPM have been initiated at BLI by our group in collaboration with the Dermatology Department at UCI using the first commercial clinical MPM system. Since 2012\, ~300 patients have been enrolled in our research studies. In this talk\, I will present results from several MPM clinical studies\, with an emphasis on our most advanced research on quantitative imaging for non-invasive early diagnosis of melanoma. Other applications include employing in vivo MPM for guiding treatment of pigmentary skin disorders and monitoring the re-pigmentation process of skin disorders such as vitiligo. These applications have been driven by novel MPM developments. In the same time\, they are driving further advances of the technology to address current barriers\, such as limited scanning area and scanning speed. I will present an overview of the current stage of development of our proposed clinical MPM platform for skin imaging that addresses these limitations\, while offering enhanced portability and reduced complexity. I will also discuss the challenges involved in the translational process of this technology and potential approaches to overcome them\, along with strategies for integrating advanced imaging with artificial intelligence-based diagnostic algorithms and with single cell transcriptomics to capture the cellular\, molecular and metabolic signatures in tissues of interest. \nBiography\nMihaela Balu\, Ph.D.\, is Associate Researcher at the Beckman Laser Institute\, UC Irvine. She has a Master in Physics and a PhD in Optics from the College of Optics and Photonics (CREOL)\, University of Central Florida. Her research is focused on integrating and advancing modern biophotonics technologies such as nonlinear optical microscopy to clinical setting. Her main goal is to use this technique as a non-invasive imaging tool for visualizing\, quantifying and understanding the morphological and underlying molecular processes in skin\, with a particular interest in melanoma and non-melanoma skin cancer. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/mihaela-balu-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/Mihaela-Balu.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190709T120000
DTEND;TZID=UTC:20190709T130000
DTSTAMP:20190629T032737Z
CREATED:20190627T043107Z
LAST-MODIFIED:20190629T032737Z
UID:21882-1562673600-1562677200@bli.uci.edu
SUMMARY:Toyohiko Yamauchi
DESCRIPTION:Associate Researcher at the Beckman Laser Institute\, UC Irvine \nQuantitative Phase Microscopy for the Evaluation of Cell Morphological Properties\nAbstract\nCell morphology and dynamics are related to a variety of significant biomedical properties\, such as the metastatic potential of cancer cells\, disease related stiffness changes in red blood cells\, pluripotency of stem cells\, and cell-to-cell interactions by tunneling nanotubules. Phase contrast microscopes or differential interference contrast microscopes are the most popular methods to evaluate the morphological features of live cells\, but these methods are not quantitative nor reproducible between different models of microscopes. For these reasons\, there has been a push to develop and validate more quantitative microscopy techniques\, such as Quantitative Phase Microscopy (QPM). QPM is an interferometry-based technique which measures the optical thickness of cells. Optical thickness is a well-defined physical property and can be used to obtain quantitative and reproducible thickness mapping of live cells within a clear background. By means of the image processing on optical thickness\, QPM enables the tracing of cell boundaries and the quantification of vectors of membrane motion. Moreover\, QPM does not require fluorescence dye (label free) and it enables long term\, time-lapse imaging of live cells for more than 48 hours. In this talk\, Toyohiko Yamauchi will introduce the theory of QPM and detail his efforts in designing\, building\, and testing QPM instruments.\nToyohiko installed his latest QPM prototype in the Beckman Laser Institute in February 2018 and has been building new research collaborations throughout UCI to develop new applications. In the latter half of this seminar\, several active collaborators will also talk about ongoing and future studies with QPM. \nBiography\nToyohiko Yamauchi graduated from the University of Tokyo with undergraduate and master’s degrees in electrical engineering. Toyohiko has been an application researcher of optical interferometry for Hamamatsu Photonics (Japan) for more than 10 years. From 2008 to 2010\, Toyohiko worked as a visiting scientist with Dr. Michael S. Feld at the MIT-Laser Biomedical Research Center to develop his quantitative phase microscope. After returning to Japan\, Toyohiko joined a government sponsored New Energy and Industrial Technology Development Organization (NEDO) project for low-invasive quality assessment of induced pluripotent stem cells from 2011 to 2014. Since then\, Toyohiko has been collaborating with biologists in both the US and in Japan for application development of QPM and he most recently spent 18 months at UCI as a visiting researcher. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/toyohiko-yamauchi/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2018/12/ToyohikoYamaychi.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190710T120000
DTEND;TZID=UTC:20190710T130000
DTSTAMP:20190704T032053Z
CREATED:20190612T010718Z
LAST-MODIFIED:20190704T032053Z
UID:21570-1562760000-1562763600@bli.uci.edu
SUMMARY:Ghazal Azarfar\, Ph.D.
DESCRIPTION:Research Assistant at the Laboratory for Surface studies\, University of Wisconsin\, Milwaukee \nLight Scattering in Diffraction Limit Infrared Hyperspectral Imaging\nAbstract\nFourier Transform Infrared (FTIR) microspectroscopy is a noninvasive technique for chemical imaging of micrometer size samples. Employing an infrared source\, a microscope coupled to a FTIR spectrometer\, and replacing a single detector with an array of detectors (128 x 128 detectors) enables collecting combined spectral and spatial information simultaneously\, resulting in wavelength dependent images which\, are being used for disease pathology and cell cycle study. In this research we are trying to remove one of the last technological barriers to the development of clinical spectroscopic cytology.\nIn diffraction limit FTIR imaging\, where the size of the sample is in the same range as the incident light\, scattering phenomenon appear in spectra as a result of the interaction of the light and matter. The observed scattering contribution dependents physical and chemical structure of the sample as well as the focusing optic and the light source. A new optimization method for correcting the scattering phenomena in pixelated infrared spectra and recovering wavelength dependent complex refractive of the sample using holographic phase images will be presented. \nBiography \nDr. Ghazal Azarfar has defended her PhD thesis in Electrical Engineering in June 2019.  She is currently working as a research assistant at the Laboratory for Surface Studies at University of Wisconsin Milwaukee (UWM). She is the president of the society for applied spectroscopy at UWM\, and has received multiple awards including the Four-Year Dean’s fellowship award\, Chancellor’s award  and Honorable Mention award. She has published a paper on Fourier transform infrared imaging of a single live cell. The focus of her research is scattering correction in the diffraction limit hyperspectral infrared imaging. Her research resulted in a new algorithm for 3D reconstruction of holographic images. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen
URL:https://bli.uci.edu/event/ghazal-azarfar/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/06/Ghazal-Azarfar.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190718T120000
DTEND;TZID=UTC:20190718T130000
DTSTAMP:20190704T034318Z
CREATED:20190704T033854Z
LAST-MODIFIED:20190704T034318Z
UID:22051-1563451200-1563454800@bli.uci.edu
SUMMARY:Bahman Anvari\, PhD
DESCRIPTION:Professor\, Department of Bioengineering\, UC Riverside \nCancer Photo-Theranostics \nAbstract\nNano-sized structures provide a platform for the delivery of imaging and therapeutic agents to tumors. When activated by light\, these structures enable visualization of small tumor nodules and their destruction through a variety of photo-transduction mechanisms. My lab focuses on the engineering of nano-sized platforms derived from biological materials\, including erythrocytes\, and their translation for cancer photo-theranostics. In this talk\, I will present some of the photophysical properties of these constructs when doped with near infrared chromophores\, and show their capabilities in targeted fluorescence molecular imaging of important cancer cell biomarkers and photo-destructions of tumor implants in animal models. I will also discuss some of the considerations necessary for clinical translation of these structures in a safe manner.     \nBiography\nBahman Anvari is a Professor in the Department of Bioengineering at UC Riverside\, and holds courtesy appointments in the Departments of Biochemistry\, and Mechanical Engineering\, and Biophysics and Biomedical Sciences Graduate Programs at UCR. He received his B.A. in Biophysics from UC Berkeley\, and Ph.D. in Bioengineering from Texas A&M University. He was a Postdoctoral Researcher at the Beckman Laser Institute\, and started his faculty career as an Assistant Professor in the Department of Bioengineering at Rice University where he became an Associate Professor.\nDr. Anvari’s scientific interests include the development and application of optical probes for biomedical imaging and therapeutic purposes. He is a co-inventor on some of the patented technologies related to the dynamic cooling of human skin.  His research activities have been continuously funded by NIH\, NSF\, and other agencies. He has published over 300 peer-reviewed and conference papers. Dr. Anvari served as an Associate Editor for the Annals of Biomedical Engineering for nearly ten years\, and is currently an Editorial Board Member of Journal of Biomedical Optics. Professor Anvari is a Fellow of American Institute for Medical and Biological Engineering (AIMBE)\, American Association for the Advancement of Science (AAAS)\, Biomedical Engineering Society (BMES)\, and the International Society for Optics and Photonics (SPIE). He is the 2019 recipient of the Caroline & William Mark Memorial Award by the American Society for Laser Medicine & Surgery (ASLMS)\, and currently serves as the Basic Science Representative at ASLMS Board. Dr. Anvari is the founder of Radoptics\, LLC\, a start-up company interested in commercialization and translation of cell-derived optical probes. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/bahman-anvari-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/07/Anvari.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190722T120000
DTEND;TZID=UTC:20190722T130000
DTSTAMP:20190704T033712Z
CREATED:20190704T032500Z
LAST-MODIFIED:20190704T033712Z
UID:22042-1563796800-1563800400@bli.uci.edu
SUMMARY:Liangzhong (Shawn) Xiang\, PhD
DESCRIPTION:Assistant Professor of Electrical and Computer Engineering at University of Oklahoma \nStephenson Cancer Center at University of Oklahoma Health Sciences Center \nX-ray-induced Acoustic Computed Tomography (XACT) \nAbstract\nX-ray computed tomography (CT) has proved tremendously useful for noninvasive medical imaging ever since its inception nearly 50 years ago. However\, there remain two major limitations: radiation harm and inaccessibility to patient.\nIn 2013\, for the first time\, we reported a novel x-ray imaging modality\, x-ray induced acoustic computed tomography (XACT)\, to overcome these limitations of conventional x-ray CT imaging. In XACT\, pulsed x-ray excitation of a sample results in localized heating\, and subsequent thermoelastic expansion\, for sufficiently short-lasting pulses\, this results in the emission of a detectable acoustic wave in the ultrasound regime\, with amplitude proportional to x-ray absorption. This unique hybrid imaging modality combines high x-ray absorption contrast with the 3D propagation advantages provided by high resolution encoding ultrasound waves. XACT imaging shows potential to produce a 3D volumetric image from a single X-ray projection. Thus\, XACT can dramatically reduce radiation dose and improve imaging speed as compared to conventional x-ray CT with hundreds of projections. Moreover\, XACT imaging also requires only single-side access to the patient versus traditional X-ray imaging’s requirement for access to two opposing sides of the patient. We expect our work may profoundly advance X-ray imaging technology.\nMy main research interest is in developing XACT imaging and enable its clinical translation. I will present a wide range of applications of XACT ranging from radiation oncology (in vivo dosimetry for external radiotherapy on breast cancer and prostate cancer)\, to radiological imaging (breast microcalcification\, bone tumor\, and osteoporosis). \nBiography\nDr. Liangzhong Xiang is an Assistant Professor in the Department of of Electric and Computer Engineering\, and Stephenson Cancer Center at University of Oklahoma (OU). Dr. Xiang received his Ph.D. degree from South China Normal University on photoacoustic molecular imaging. He was a postdoctoral fellow trained in medical physics at Stanford Medical School\, and he awarded the U.S. Department of Defense (DoD) Prostate Cancer Postdoctoral Training Program at Stanford University (2012-2015).\nIn research\, Dr. Xiang and his laboratory was the first to report x-ray-induced acoustic computed tomography (XACT). His work on XACT imaging was the cover article for Medical Physics in 2013. His talk entitled “X-ray acoustic computed tomography: concept and design” has been identified as a “Hot Topic” presentation for the 2013 AAPM Annual Meeting. And he received the Slvia Sorkin Greenfield Award for the best paper of the Medical Physics at AAPM 50th Annual Meeting.  His research has led to over 60+ peer-reviewed publications\, 12 patents\, 30+ presentations. Sponsored by NIH\, DoD and Oklahoma state funding agencies with over $ 3 million dollars active grant support. In education\, he received Nancy L. Mergler Faculty Mentor Award for Undergraduate Research (the only recipient at OU in 2017). He strategically guides lab students to become extraordinary and independent scientists. His students have been awarded SPIE Education Scholarship (2019\, 2018)\, SPIE Travel Scholarship (2016). His postdoctoral research fellows were awarded the Trainee Research Prize from the Radiological Society of North America (RSNA\, 2015). In service\, Dr. Xiang has served as conference chairs in AAPM annual meeting (2019) and International Conference on Information Optics and Photonics (CIOP 2018)\, SPIE Student Chapter advisor\, associate editor of Medical Physics journal\, and grant reviewer for U S Department of Energy\, Russian Science Foundation (RSF)\, and Helmholtz Association of German Research Centre. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://bli.uci.edu/event/liangzhong-xiang-phd/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2019/07/Liangzhong-Xiang.jpg
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