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DTSTART:20190101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20200210T120000
DTEND;TZID=UTC:20200210T130000
DTSTAMP:20200111T073656Z
CREATED:20200111T051746Z
LAST-MODIFIED:20200111T073656Z
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SUMMARY:Professor Alfred Vogel
DESCRIPTION:Institute of Biomedical Optics\, University of Lüebeck\, Germany \nFree-electron-mediated modifications of biomolecules: from photodamage in nonlinear microscopy to intentional photomodification of cells and tissues \n\nAbstract\nFemtosecond laser-induced plasma generation is used surgically and may also cause photodamage in nonlinear microscopy. The irradiance threshold at which transient vapor bubbles in water are produced by single pulses is 20 times higher than the irradiance used for microscopy. However\, photodamage in multiphoton microscopy already starts\, when the irradiance is raised 1.5 times above the value used for autofluorescence imaging. The huge realm of low-density plasma effects between multi-pulse nonlinear imaging and single-pulse surgical regime is little explored. We provide a systematic overview over irradiance and radiant exposure dependence of laser effects in this regime. Surgery by single-pulses relies on the disruptive effect of nm to µm sized transient cavitation bubbles. The threshold is here determined by a critical temperature above which a phase transition occurs. Series of low-energy fs pulses induce free-electron mediated modifications and finally disintegration of biomolecules. Bubble here contain non-condensable gas rather than water vapor. The underlying process is a nonlinear chemical rate process\, and threshold characteristics differ fundamentally from the single-pulse threshold. Below bubble threshold\, photomodifications can be utilized to create corneal refractive changes suitable for non-ablative treatment of myopia and hyperopia. Photodamage in multiphoton microscopy was explored for various cell types and tissues using physical indicators enabling real-time-monitoring of the damage kinetics. We characterize the transition from unchanged tissue (emitting autofluorescence) to slightly changed tissue (hyperfluorescence)\, drastically changed tissue (plasma luminescence) and finally molecular disintegration leading to gas bubble formation. By plotting the threshold values in (irradiance\, radiant exposure) space\, we can clearly identify a “safe” region for nonlinear microscopy and separate it from regions for different types of photomodification.  \nBiography\nProf.  Alfred Vogel is Team Leader and former Director of the Institute of Biomedical Optics (BMO)\, University of Luebeck\, Germany. Hereceived the Ph.D. degree in Physics from University Goettingen in 1987\, and the degree of Habilitated Doctor of Physics from the University of Luebeck\, Germany\, in 1999. Since 2010 he is also Adjunct Professor of Xiʼan Jiaotong University\, PR China. Dr. Vogel is fellow of the Optical Society (OSA) and of SPIE. He has published over 90 peer-reviewed jounral articles and 51 proceedings papers. His published work has received over 12\,000 citations with a h-index of 47. He holds 11 patents.\n          Dr. Vogel has made major experimental and theoretical contributions to the field of pulsed laser interactions with molecules\, cells and biological tissues.  He developed comprehensive theoretical frameworks for pulsed laser tissue interactions ranging from photochemical changes to ablation\, and for controlled nonlinear energy deposition in transparent dielectrics.\nHe invented new technologies for imaging and characterization of plasmas\, shock waves\, cavitation bubbles\, and ablation plume dynamics. His research encompasses surface ablation through linear absorption of ultraviolet and infrared laser pulses\, ablation processes in a liquid environment such as in blood vessels or joints\, as well as precise plasma-mediated ablation\, surgery\, and molecular modificationswithin nominally transparent materials such as ocular tissues and cells.  His work in these areas hasled to innovative strategies for improving cellular micro/nano surgery\, intraocular surgery\,and refractive surgery.\n          Dr. Vogel served on the editorial board for the Journal of Biomedical Optics (2002-2019)\, served as associate editor of Optics Express (2006-2009)\, and as advisory editor of Biomedical Optics Express (2010-2019). \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova.\nSponsored by the Berns Family Laser and Microbeam Program
URL:https://bli.uci.edu/event/alfred-vogel/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2020/01/Vogel-Head-Shot.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20200213T123000
DTEND;TZID=UTC:20200213T133000
DTSTAMP:20200206T024504Z
CREATED:20200206T024504Z
LAST-MODIFIED:20200206T024504Z
UID:27752-1581597000-1581600600@bli.uci.edu
SUMMARY:The Potential of Digital Histopathology Using Label-Free Optical Imaging Techniques
DESCRIPTION:Woonggyu Jung\, Ph. D.  \nUlsan National Institute of Science and Technology\, Korea \nThe Potential of Digital Histopathology Using Label-Free Optical Imaging Techniques\n  \nAbstract \nThe histological optical imaging is a gold standard method to observe the biological tissues\, which follows routine process such as dissection\, embedding\, sectioning\, staining\, visualization and interpretation of specimens. This technique has a long history of development\, and is used ubiquitously in pathology\, despite being highly time and labour-intensive. Advanced optical imaging techniques developed over the last decade have enabled to provide high sensitivity\, high resolution and non-invasive biological information. However\, acquiring high throughput\, large volume tissue anatomy remains a difficult challenge due to the effect of light scattering\, which limits the penetration imaging depth and lateral resolution. Recently\, various optical imaging methods have been introduced to create volumetric anatomy data of ex vivo tissues using physical tissue sectioning or optical clearing. Even though these new approaches present the distinguished volumetric anatomy in various scales\, they are still not suitable for use in statistical studies with multiple tissues and organs. Here\, we introduce novel label-free and multi-scale imaging modality based on serial optical coherence microscopy (OCM). OCM is a potential technique to build volumetric anatomy of mouse tissues or organs due to its simplicity\, efficiency\, robustness\, and high-throughput capabilities. This presentation covers the latest work of large-scale brain and kidney imaging using OCM and its potential in bio-applications. Specifically\, the talk will highlight other label-free optical imaging modalities including wide-field quantitative phase microscopy and optical projection tomography toward to multi-scale histopathology. \nBiography \nWoonggyu Jung received his Ph. D. in 2008 from the Department of Biomedical Engineering at the University of California\, Irvine. From 2001 to 2008\, he worked at the Beckman Laser Institute and Medical Clinic at UC Irvine. He also worked at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign since January 2009. He has joined the faculty of UNIST in 2012\, and currently works as an associate professor of Department of Biomedical Engineering. He is also co-founder and CTO of start-up company\, Conecson which is focused on the futuristic business regarding to mobile-based medical devices. Dr. Jung has a strong research background in optical imaging technologies including optical coherence tomography (OCT)\, quantitative phase microscope (QPM)\, and miniaturized optical imaging probes. His research interest is to develop new optical technologies that address challenges in clinical medicine\, basic biological research and neuroscience. In previous work\, he developed a successful optical platform for in vivo translational research\, and has published more than 60 peer-reviewed journal papers in the field of biophotoics. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Zhongping Chen
URL:https://bli.uci.edu/event/woonggyu-jung/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2020/02/Woonggyu-Jung.jpg
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DTSTART;TZID=UTC:20200227T120000
DTEND;TZID=UTC:20200227T130000
DTSTAMP:20200212T025402Z
CREATED:20200212T024829Z
LAST-MODIFIED:20200212T025402Z
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SUMMARY:Dr. Vivek Jay Srinivasan
DESCRIPTION:Associate professor of Biomedical Engineering and Ophthalmology at the University of California\, Davis \nHuman Brain Interferometers for Better Blood Flow Monitoring \nAbstract \nSteady cerebral blood flow (CBF) is needed for normal brain function\, but continuous monitoring of CBF in humans is currently challenging.  Here\, by leveraging a low-cost sensor technology\, we introduce a class of novel near-infrared optical devices that monitor CBF continuously and non-invasively in adult humans.  We achieve this by replacing expensive single photon counting detectors\, currently used for optical CBF monitors\, with complementary metal–oxide–semiconductor (CMOS) arrays. We maintain performance by employing an additional optical “trick” known as interferometry\, which transforms each CMOS pixel into a sensitive detector for fluctuations of coherent light that probes blood flow in the brain.   Our method is called interferometric Diffusing Wave Spectroscopy (iDWS).  Since CMOS camera pixels are cheap and numerous\, iDWS both improves the performance and reduces the cost of optical CBF monitoring\, enabling record brain-to-scalp sensitivity. By liberating CBF monitoring from photon counting\, iDWS enables measuring CBF continuously in a new environments. In this talk we describe technical advantages of iDWS relative to conventional methods\, and broadly envisage how interferometry can help to advance the field of diffuse optics. \nBiography \nVivek Srinivasan is Associate Professor of Biomedical Engineering and Ophthalmology and Chancellor’s Fellow at UC Davis. His group develops new light-based technologies for in vivo imaging and sensing of the brain and eye.  Starting with a firm grounding in neurophysiology and biomedical engineering\, his group employ ideas novel photonic technologies and approaches to accomplish this goal. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Bernard Choi
URL:https://bli.uci.edu/event/vivek-srinivasan/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2020/02/Vivek.jpg
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