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X-WR-CALDESC:Events for Beckman Laser Institute
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DTSTART;TZID=UTC:20211007T120000
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SUMMARY:Quinton Smith\, Ph. D.
DESCRIPTION:Harnessing Physiological Forces to Drive Stem Cell Fate & Function \nAbstract\nI will be elaborating about how physical cues are crucial to embryonic development\, morphogenic events\, and tissue organization\, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues. As such\, the role of substrate stiffness\, fluid shear stress\, and confinement was interrogated on stem cell derived endothelial cell differentiation efficiency and functionality. We find priming hiPSCs on compliant substrates\, as opposed to traditionally used rigid plastic surfaces\, promotes efficient endothelial specification in the absence of growth factor supplementation. Leveraging micropatterned domains\, which restrict extracellular matrix accessibility\, also enhances endothelial specification and early lineage organization. Finally\, using a microfluidic platform\, we find that primary cilia\, a microtubule-based mechanosensor\, is crucial to stem cell derived endothelial shear response. Collectively\, we can investigate the role of biophysical stimuli on cell fate and function using a variety of engineering tools. \nBiography\nQuinton Smith is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Sue & Bill Gross Stem Cell Research Center\, Irvine. Quinton Smith received his bachelor’s degree from the University of New Mexico in\nchemical engineering and his Ph.D. in 2017 from Johns Hopkins University in chemical and biomolecular engineering. His predoctoral research was supported by an NIH/NHLBI F-31 and NSF Graduate Research Fellowship. Additionally\, he was named a Siebel Scholar in 2017. After completing his doctorate\, he trained as a Howard Hughes Medical Institute Hanna Gray Postdoctoral Fellow at the Massachusetts Institute of Technology. Dr. Smith joined the University of California Irvine in Spring 2021 and is currently an Assistant Professor in the Department of Chemical and Biomolecular Engineering and a member of the Sue Bill Gross Stem Cell Research Center. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/quinton-smith-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2022/06/Quinton_Smith.jpg
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DTSTART;TZID=UTC:20211014T120000
DTEND;TZID=UTC:20211014T130000
DTSTAMP:20211014T010429Z
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SUMMARY:Erin Buckley\, Ph. D.
DESCRIPTION:Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies \nAbstract\nOur research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive\, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar\, I will focus on our recent work that uses these tools to identify biomarkers of stroke risk in two high-risk patient populations; subarachnoid hemorrhage and pediatric sickle cell disease. Moreover\, I will talk about how we have advanced the techniques to account for the confounding influences of hematocrit in the sickle cell cohort. \nBiography\nDr. Buckley is an Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. She is also an assistant professor at the Department of Pediatrics at Emory University. She received her PhD from the Department of Physics and Astronomy from the University of Pennsylvania in 2011 and completed postdoctoral training at the Children’s Hospital of Philadelphia and at Massachusetts General Hospital. Her research focuses on the development and validation of diffuse optical spectroscopies. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://bli.uci.edu/event/erin-buckley-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://bli.uci.edu/wp-content/uploads/2021/10/Dr-Buckley-1.jpg
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