A fresh study discovers a novel reason for brain hemorrhages, not just blood vessel injury
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The discovery that cerebral microbleeds can be caused by mature red blood cells interacting with brain capillaries is the result of recent research, which contradicts the belief that these bleeding events occur solely due to blood vessel damage.
A new finding from the University of California, Irvine has revealed that cerebral microbleeds can be caused by a combination of older red blood cells and brain capillaries.
The discovery contributes to a better understanding of the mechanisms behind these bleeding, which can lead to the development of new therapeutic interventions to manage and prevent these conditions.
Recent research published in the Journal of Neuroinflammation reveals that the team observed how red blood cells stall in brain capillaries and analyzed the process of hemorrhage.
Dr. Mark Fisher, a neurology professor at UCI’s School of Medicine, emphasized the importance of this study in extending our understanding of the mechanism behind cerebral microbleeds.
After tert-butyl hydroperoxide was exposed to them, the team used a fluorescent label to mark the cells and inject them into mice. They observed that the red blood cells became trapped in the brain capillaries and then cleared out in endothelial erythrophagocytosis, leading to hemorrhage in the brain as microglia engulfed the cells as they moved out of the capillaries.
It has long been thought that blood vessels must be injured or disrupted to cause cerebral hemorrhage, but additional research suggests that increased red blood cell interactions with brain capillaries offer a unique means of development.
The findings, published in the democratic college in New York on October 18, 2017, suggest that learning or movement through connections between retinal and cynical nerves may result in milder symptoms, which could indicate cancer progression.
Rachita Sumbria, Hai Zhang, Rudy Chang, Jiahong Sun, David Cribbs, and Todd Holmes worked together to maximize the benefits of the Center for Neural Circuit Mapping’s comprehensive infrastructure and robust resources.
The National Institute on Aging and the National Institute of Neurological Disorders and Stroke donated their support for this work.
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