Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles
Abstract
To improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event, plasmonic nanobubble, results from a novel physical-biological mechanism. Its mechanical impact was tuned to support cell level diagnostics, drug release and intracellular injection of genetic or therapeutic payloads, to enhance chemoradiation therapies in highly resistant and aggressive tumors, to intraoperatively detect and destroy unresectable residual microtumors, and to non-invasively detect bad actors, all in personalized procedures with safe doses of nanoparticles and laser energies. Plasmonic nanobubble platform can be integrated with current or novel medical approaches to improve clinical outcomes where standards of care fail.
Biography
Dmitri Lapotko obtained his MS in thermal physics and Ph.D. in laser applications from Belarus State University and Doctor of Science in bioengineering from Lyikov Heat and Mass Transfer Institute. His research in biophotonics and nanotechnology in basic, applied and clinical science resulted in the invention of photothermal microscope for functional analysis of live cells, laser-generated vapor nanobubbles (plasmonic nanobubbles) as a novel platform for diagnostic, therapeutic and surgical technologies for cancer, malaria and cardiovascular disease applications.
