In vivo multiphoton microscopy of microvasculature and inflammation: Lessons from the brain and a look at the heart Abstract In vivo multiphoton microscopy enables the visualization of dynamics at the cellular scale and is an ideal tool for studying the interactions of cells in vivo. Such imaging has revealed the importance of maintaining vascular health, […]
Cell Mechanics by Light Abstract Living cells are active matter characterized by mechanical properties as stiffness and deformability and morphological parameters as shape and volume. Genetic or pathogenic modifications of these properties can affect cell behavior. Since these transformations are potential indicators in various pathologies, cell mechanics characterization has progressively gained interest. However, due to […]
Fluorophores with a Genome: DNA-Stabilized Silver Clusters as a New Class of Tunable Fluorophores for Microscopy and Biosensing Abstract Because near-infrared (NIR) electromagnetic radiation penetrates much farther into biological tissues than visible light, NIR microscopy allows for noninvasive imaging deep into tissues and even whole organisms. In the second near-infrared window (NIR-II: 1,000-1,700 nm), biological […]
Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies Abstract Our research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar, I will focus on our recent work that uses these tools to identify biomarkers of […]
Vasculopathy in COVID-19 and Pathogenesis of Cutaneous Vascular Malformations Abstract SARS-CoV-2-associated vasculopathy under hyperlipidemia and pathological progression of congenital vascular abnormalities in Port Wine Stains. In the first part, we will present our clinical data for the first discovery of dyslipidemia in COVID-19 patients which have been substantially recognized. Mechanistically, we have shown evidence of […]
Light + Sound: Peering into Brain Function and Metabolism Abstract Exploiting the optical absorption contrast of blood hemoglobin, photoacoustic microscopy (PAM) is an emerging technology for label-free imaging of the microvasculature, which plays an essential role in supplying oxygen to the biological tissue and maintaining the metabolic activity in vivo. The multi-parametric PAM developed in […]
Confocal Microscopy for the Evaluation of OcularSurface Disease Abstract Diagnosis and treatment of ocular surface disease represents a large proportion of the average ophthalmologist’s practice. However, this group of conditions is more heterogeneous and complex than the term “dry eye” conveys. Further investigation of the pathophysiologic mechanisms underlying these conditions are underway, and in […]
Laser Beam Shaping for Surgery and Microbiopsy Abstract Lasers are increasingly being used for surgery in a wide range of medical specialties due to their advantages over alternative surgical tools. Advantages include precise material removal, limited bleeding, and delivery through optical fibers enabling use in body cavities and for minimally invasive surgeries. Advancements in […]
Commercialization and searching for a business model: why is spinning technology out of a lab so challenging? Abstract In this talk, we will explore the four critical challenges of getting technology out of a lab. Dr. Arkilic, Chief Innovation Officer of UCI has spent his entire career in supporting getting technology out of Academic labs. […]
True multi-modality optical molecular imaging – where both modalities interact and work in harmony. Abstract The main goal of the molecular imaging community has been achieving higher resolution and better quantitative accuracy. For nearly two decades, I have been spending effort for the same purpose, mainly integrating optical imaging with anatomic imaging modalities such as […]
