Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies Abstract Our research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar, I will focus on our recent work that uses these tools to identify biomarkers of […]
Vasculopathy in COVID-19 and Pathogenesis of Cutaneous Vascular Malformations Abstract SARS-CoV-2-associated vasculopathy under hyperlipidemia and pathological progression of congenital vascular abnormalities in Port Wine Stains. In the first part, we will present our clinical data for the first discovery of dyslipidemia in COVID-19 patients which have been substantially recognized. Mechanistically, we have shown evidence of […]
Light + Sound: Peering into Brain Function and Metabolism Abstract Exploiting the optical absorption contrast of blood hemoglobin, photoacoustic microscopy (PAM) is an emerging technology for label-free imaging of the microvasculature, which plays an essential role in supplying oxygen to the biological tissue and maintaining the metabolic activity in vivo. The multi-parametric PAM developed in […]
Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles Abstract To improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event, […]
Applications of Spatial Frequency Domain Imaging in Thyroid Eye Disease Abstract Spatial frequency domain imaging provides access to multi-spectral absorption and scattering information of biological chromophores and water to provide quantifiable detail about tissue hemodynamics and spectral content. We propose to use SFDI to define an optical signature map characteristic for healthy eyes, and TED […]
Tunable photonic nanostructures for laser pulse control and dynamic imaging Abstract For decades, nanofabrication has been the driving force behind the transformations in electronics. Light-based devices currently experience a similar transition: nanostructure-based photonic elements bear promise to revolutionize several key technology areas, such as telecommunications, augmented reality, remote sensing, and imaging. In this talk, I […]
Opportunities to Improve Clinical Outcomes with Intravascular Ultrasound (IVUS) in Lower Extremity Revascularizations Abstract Peripheral vascular disorders are prevalent and mounting health conditions, particularly in light of the aging population. Both acute and chronic arterial and venous disease result in excess morbidity and mortality and dramatically reduce health-related quality of life. Yet, despite the expanded […]
Technology Transfer and Entrepreneurship at UCI Abstract This seminar will discuss “technology transfer”, the process by which UCI (1) protects intellectual property (inventions and software) developed by its faculty, staff, researchers and grad students; and (2) commercializes this IP through licensing to an existing company or startup. Also discussed will be the services and resources […]
FLIM and Mitometer enable metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells Abstract The hallmark of metabolic alteration of increase glycolysis, i.e. Warburg effect, in cancer cells together with atypical extracellular matrix structure may be responsible for tumor cell aggressiveness and drug resistance. While it is it known that tumor cells stiffen […]
Intervascular Imaging & Treatment Seminar About Dr. Giulio Guagliumi was trained with Master in Interventional Cardiology at the Clinique Pasteur, Toulouse, France. He was awarded at Mayo Clinic and St. Mary Hospital, Rochester in imaging and coronary physiology assessment of vascular response to intracoronary stents. He has a long-standing interventional practice with research expertise in acute myocardial […]
